ARFGEF2
-
Official Full Name
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -
Overview
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. -
Synonyms
ARFGEF2;ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited);brefeldin A-inhibited guanine nucleotide-exchange protein 2;BIG2;Brefeldin A inhibited guanine nucleotide exchange protein 2;brefeldin A-inhibited GEP 2;PVN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARFGEF2-1847M | Recombinant Mouse ARFGEF2 Protein | Mammalian Cell | Mouse | His |
|
|
| ARFGEF2-756R | Recombinant Rat ARFGEF2 Protein | Mammalian Cell | Rat | His |
|
|
| ARFGEF2-412R | Recombinant Rat ARFGEF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| ARFGEF2-412R-B | Recombinant Rat ARFGEF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| ARFGEF2-666M | Recombinant Mouse ARFGEF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| ARFGEF2-666M-B | Recombinant Mouse ARFGEF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
ARFGEF2 involved in several pathways and played different roles in them. We selected most pathways ARFGEF2 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | HSPA6,PRKCI,CBLB,RAB11FIP2,GRK1,EPN1,DNM1A,RAB5C,DNM3,PARD6B |
Protein Function
ARFGEF2 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity,GABA receptor binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFGEF2 itself. We selected most functions ARFGEF2 had, and list some proteins which have the same functions with ARFGEF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ARF guanyl-nucleotide exchange factor activity | CYTH3,GBF1,CYTH4B,CYTH4,CYTH1,CYTH1A,PSD3,PSD2,FBXO8,CYTH2 |
| protein kinase A regulatory subunit binding | AKAP5,RYR2,KCNQ1,AKAP9,AKAP7,AKAP6,EZR,AKAP1,ACBD3,PJA2 |
| guanyl-nucleotide exchange factor activity | RALGDS,DOCK4,ARHGEF7A,RASGRP2,PTGIR,DOCK11,RAPGEF4,FGD6,RASGEF1BB,VAV2 |
| GABA receptor binding | MAF1,GABRG1,GABARAP,JAKMIP1,AKAP5,GABRB1,GABARAPL2,GABRA5,PLCL1,PLCL2 |
| myosin binding | GIPC1,KIRREL,CALD1B,RHOA,FXYD1,ACTC1,TRIM32,MYBPC3,SMYD1B,VETZ |
Interacting Protein
ARFGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFGEF2.
Iqcb1
Resources
Related Services
Related Products
References
