ARFGAP1
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Official Full Name
ADP-ribosylation factor GTPase activating protein 1 -
Overview
The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARFGAP1;ADP-ribosylation factor GTPase activating protein 1;ADP ribosylation factor 1 GTPase activating protein , ARF1GAP;ADP-ribosylation factor GTPase-activating protein 1;bA261N11.3;FLJ10767;ARF1 GAP;ARF GAP 1;GAP protein;ARF1-directed GTPase-
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Human
- Rat
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ARFGAP1 involved in several pathways and played different roles in them. We selected most pathways ARFGAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | GRK1A,RAB11BA,ARF5,LDLRAP1B,WWP1,SH3GL3A,GIT1,RAB11FIP2,RET,EHD1 |
Protein Function
ARFGAP1 has several biochemical functions, for example, GTPase activator activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFGAP1 itself. We selected most functions ARFGAP1 had, and list some proteins which have the same functions with ARFGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CXCL11,OGG1,IL17A,INPP5A,LPAR2,NIPSNAP1,TEN1,HNRNPD,EIF3A,CDH2 |
| GTPase activator activity | RASA4,FAM13B1,ARHGAP19,SOS1,SIPA1L1,SRGAP2,CDC42EP5,GARNL3,AGFG1A,ARHGAP4A |
| metal ion binding | ZBTB41,RNF11A,ZBTB37,PFKMB,FRAS1,ACSM5,LNX2,PHLPP1,IMPDH1,NUBPL |
Interacting Protein
ARFGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFGAP1.
GRN;TRIM23;KRTAP10-9;GABARAPL2;FOS;KRTAP9-2;KRTAP3-2
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References
- Wonderlich, ER; Leonard, JA; et al. ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells. JOURNAL OF VIROLOGY 85:12216-12226(2011).
- Saeki, N; Tokuo, H; et al. BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. JOURNAL OF BIOLOGICAL CHEMISTRY 280:10128-10134(2005).
