ARAP2
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Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -
Overview
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. -
Synonyms
ARAP2;ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2;centaurin, delta 1 , CENTD1;arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2;PARX;cnt-d1;centaurin-delta-1;centaurin, delta 1;Arf and Rho GAP adapter protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARAP2-9791H | Recombinant Human ARAP2, His-tagged | E.coli | Human | His | C-term-349a.a. | |
| ARAP2-90H | Recombinant Human ARAP2 protein, His-tagged | E. coli | Human | His | His81-Ser240 |
|
Involved Pathway
ARAP2 involved in several pathways and played different roles in them. We selected most pathways ARAP2 participated on our site, such as Arf6 signaling events,Endocytosis,Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rho GTPase cycle | ARHGAP23,ARHGAP1,ARHGAP17B,FAM13B,ARHGAP19,ARHGAP15,ARHGAP4A,OBSCN,ARHGAP4,ARHGEF17 |
| Signal Transduction | ANXA1A,NRP2,RGS1,SPRY1,RHPN1,ABCA4A,OXTRL,PROK2,SDR9C7,C |
| Endocytosis | VPS29,RAB11FIP2,ARAP1,CHMP1B,RAB11FIP4,DAB2,STAM,HLA-C,TFR1A,PLD1 |
| Arf6 signaling events | EGFR,IPCEF1,FBXO8,AGTR1,ADRB2,ADAP1,GULP1,USP6,EGF,EPHA2 |
| Signaling by Rho GTPases | ARHGAP33,ARHGAP10,ARHGAP19,ARHGAP36,ARHGAP11A,NOXO1A,ARHGEF16,ARHGAP20,ARHGAP29B,ARHGAP17A |
Protein Function
ARAP2 has several biochemical functions, for example, GTPase activator activity,metal ion binding,phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAP2 itself. We selected most functions ARAP2 had, and list some proteins which have the same functions with ARAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | BAI3,ALS2CL,TBC1D25,ARHGAP18,GMIP,TBC1D4,EVI5,ACAP1,RGS17,ARHGAP24 |
| metal ion binding | ZNF350,ZFP629,GALNTL1,NEURL1AA,COL27A1A,CYP2D26,ZNF286A,SMYD1B,SMYD2A,GTSF1L |
| phosphatidylinositol-3,4,5-trisphosphate binding | NRGN,PARD3,KIF16B,COMMD1,ADAP2,GBF1,ASAP1,INPPL1,GAB2,PIRT |
Interacting Protein
ARAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAP2.
Dlg4;q81nr7_bacan;malK
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References
- Chen, PW; Luo, RB; et al. The Arf6 GTPase-activating Proteins ARAP2 and ACAP1 Define Distinct Endosomal Compartments That Regulate Integrin alpha 5 beta 1 Traffic. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30237-30248(2014).
- Jung, EJ; Park, HB; et al. Genome-wide association study identifies quantitative trait loci affecting hematological traits in an F-2 intercross between Landrace and Korean native pigs. ANIMAL GENETICS 45:534-541(2014).
