APOL1
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Official Full Name
apolipoprotein L, 1 -
Overview
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. -
Synonyms
APOL1;apolipoprotein L, 1;APOL;apolipoprotein L1;APO L;Apo-L;APOL I;ApoL-I;APOL1_HUMAN;APOLI;Apolipoprotein L;Apolipoprotein L I;Apolipoprotein L-I;OTTHUMP00000028705;OTTHUMP00000197952;OTTHUMP00000197984;OTTHUMP00000197985;OTTHUMP00000197986;OTTHUMP00000197987;OTTHUMP00000198062;FSGS4
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Insect Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
APOL1 involved in several pathways and played different roles in them. We selected most pathways APOL1 participated on our site, such as African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| African trypanosomiasis | HPR,HBA-A2,IL12B,FASLG,HBA2,SELE,THOP1,PRKCB,IDO2,IL12A |
Protein Function
APOL1 has several biochemical functions, for example, chloride channel activity,lipid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOL1 itself. We selected most functions APOL1 had, and list some proteins which have the same functions with APOL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chloride channel activity | GABRE,SLC26A11,CLCA4,TTYH3,SLC1A4,GABRA5,GABRA6A,CLIC5A,SLC26A6,CLCA2 |
| lipid binding | C3,STARD13,APOA4B.1,PACSIN1B,O3far1,SNX27,MTTP,FABP10A,BPIFB2,UNC119B |
| protein binding | GSPT2,CCER1,TBC1D22B,CTCF,KLF11,GNAT1,COL23A1,PEBP1,OSBPL3,DHX8 |
Interacting Protein
APOL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOL1.
CDC23;IGHM
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