APOBEC3A
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Official Full Name
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A -
Overview
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. One allele of this gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3A, and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3 UTR of APOBEC3B. -
Synonyms
APOBEC3A;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A;ARP3;phorbolin I;PHRBN
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- HEK293
- Mammalian Cell
- E. coli
- Yeast
- Mamanlian cells
- GST
- Myc&DDK
- His
- Non
- His&SUMO
- His&Fc&Avi
- Flag
Involved Pathway
APOBEC3A involved in several pathways and played different roles in them. We selected most pathways APOBEC3A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APOBEC3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
APOBEC3A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by APOBEC3A itself. We selected most functions APOBEC3A had, and list some proteins which have the same functions with APOBEC3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
APOBEC3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOBEC3A here. Most of them are supplied by our site. Hope this information will be useful for your research of APOBEC3A.
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References
- Tasker, C; Ding, J; et al. 17 beta-Estradiol Protects Primary Macrophages Against HIV Infection Through Induction of Interferon-Alpha. VIRAL IMMUNOLOGY 27:140-150(2014).
- Rathore, A; Carpenter, MA; et al. The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5 '-CC to 5 '-TC by a Single Amino Acid Substitution. JOURNAL OF MOLECULAR BIOLOGY 425:4442-4454(2013).
Reviews
Q&As
Yes, our APOBEC3A proteins can be used in Western Blot.