APH1B
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Official Full Name
anterior pharynx defective 1 homolog B (C. elegans) -
Overview
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. -
Synonyms
APH1B;anterior pharynx defective 1 homolog B (C. elegans);gamma-secretase subunit APH-1B;APH 1B;DKFZp564D0372;PSFL;Anterior pharynx defective 1 homolog B;Anterior pharynx defective 1B like;Anterior pharynx defective 1b short splicing variant;Aph 1beta;APH-1b;Aph-1beta;Aph1 beta;APH1B_HUMAN;Aph1beta;Gamma secretase subunit APH 1B;Gamma secretase subunit APH1B;Gamma secretase sununit;Presenilin stabilisation factor like;Presenilin-stabilization factor-like;PRO 1328;PRO1328;TAAV 688;TAAV688
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Pongo Abelii
- zebrafish
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
APH1B involved in several pathways and played different roles in them. We selected most pathways APH1B participated on our site, such as Notch signaling pathway,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APH1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | NDUFA6,GRIN2C,GAPDH,CALM4,ERN1,NAE1,CDK5,NDUFV1,ATF6,NDUFC2-KCTD14 |
| Notch signaling pathway | NOTCH1B,RBPJB,DTX4,RBPJ,CNTN6,DLL1,DVL1B,KAT2A,ADAM12,NOTCH3 |
Protein Function
APH1B has several biochemical functions, for example, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APH1B itself. We selected most functions APH1B had, and list some proteins which have the same functions with APH1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | PSMB5,PSEN1,Ren1,CPNE1,MMP1,PSMB9A,HTRA4,PARL,PSMB10,F9 |
Interacting Protein
APH1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APH1B here. Most of them are supplied by our site. Hope this information will be useful for your research of APH1B.
APH1B Related Signal Pathway
Resources
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References
- Fazzari, P; Snellinx, A; et al. Cell autonomous regulation of hippocampal excitatory circuitry via Aph1b-gamma-secretase/Neuregulin 1 signalling. ELIFE 3:-(2014).
- Acx, H; Chavez-Gutierrez, L; et al. Signature Amyloid beta Profiles Are Produced by Different gamma-Secretase Complexes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4346-4355(2014).
