APC2

  • Official Full Name

    adenomatosis polyposis coli 2

  • Overview

    APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.

  • Synonyms

    APC2;adenomatosis polyposis coli 2;APCL;adenomatous polyposis coli protein 2;adenomatous polyposis coli like
Cat.# Product name Source (Host) Species Tag Protein Length Price
APC2-3154H Recombinant Human APC2, His-tagged E.Coli/Yeast Human His 2303
APC2-4062C Recombinant Chicken APC2 Mammalian Cells Chicken His

    Involved Pathway

    APC2 involved in several pathways and played different roles in them. We selected most pathways APC2 participated on our site, such as Basal cell carcinoma,Colorectal cancer,Endometrial cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of Actin Cytoskeleton FGFR2,FN1A,RHOAB,GNA12,ARPC5LA,PIP5K1C,CDC42,SCINLA,ACTB2,WASB
    Colorectal cancer TCF7L2,TCF7,SMAD4,PIK3CA,CCND1,TGFB3,TGFB2,MSH2,MSH3,APC
    HTLV-I infection H2-AB1,CD3D,TGFBR2,CDC16,SMAD4,ANAPC4,HLA-DPA1,FZD6,HRAS,APC
    MicroRNAs in cancer EZR,PIK3R2,PRKCA,CD44,ERBB2,MAPK7,Abcb1b,ZFPM2,Casp3,MDM2
    Endometrial cancer ILK,MAPK3,NRAS,CDH1,MAPK1,CTNNA2,PIK3CA,ARAF,PIK3R3,MLH1
    Hippo signaling pathway PRKCZ,STK3,BMP6,PARD6A,AXIN1,JUB,WNT5B,PPP2R2B,WNT11,BMP4
    Pathways in cancer RARA,TCEB2,ITGA3,Flt3l,RELA,FZD10,ROCK2,FZD1,FGF2,WNT1
    Basal cell carcinoma WNT3A,Shh,WNT4,WNT2,BMP4,WNT3,GLI2,HHIP,PTCH1,APC

    Protein Function

    APC2 has several biochemical functions, for example, beta-catenin binding,gamma-catenin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APC2 itself. We selected most functions APC2 had, and list some proteins which have the same functions with APC2. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding KIF5AA,RCC2,DPYSL5B,MAP2,NUSAP1,TRIM54,KIFC3,CAMSAP1,HDAC6,NUMA1
    beta-catenin binding LZTS2A,DACT2,SLC9A3R2,DACT3,SOX17,TRPC4,LZIC,CTNNA3,MED12L,TAX1BP3
    protein binding GAB2,RGL2,ALOX12,RYK,DHX38,OCLN,ZWINT,HEPACAM2,AKR1C1,MLLT3
    gamma-catenin binding CDH1,Fert2,DSG1,CDH2,APC,PTPRJ,FER,PTPRK,CTNNA1,LEF1

    Interacting Protein

    APC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APC2.

    MAPRE3;TP53BP2;MAPRE1;TIMP2;YBX1

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