APC2
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Official Full Name
adenomatosis polyposis coli 2 -
Overview
APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor. -
Synonyms
APC2;adenomatosis polyposis coli 2;APCL;adenomatous polyposis coli protein 2;adenomatous polyposis coli like
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APC2-3154H | Recombinant Human APC2, His-tagged | E.Coli/Yeast | Human | His | 2303 |
|
| APC2-4062C | Recombinant Chicken APC2 | Mammalian Cells | Chicken | His |
|
Involved Pathway
APC2 involved in several pathways and played different roles in them. We selected most pathways APC2 participated on our site, such as Basal cell carcinoma,Colorectal cancer,Endometrial cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endometrial cancer | MAP2K2,PIK3CG,PIK3R1,CCND1,AKT2,MAPK1,AKT1,ARAF,BRAF,PIK3CB |
| Basal cell carcinoma | WNT8B,WNT2B,Shh,WNT11,FZD5,BMP4,STK36,WNT16,WNT6,WNT10B |
| HTLV-I infection | GSK3B,CDC23,WNT3A,TRP53INP1,NRP1,NFATC2,HLA-DQA1,HLA-DOB,CD3G,SMAD4 |
| Colorectal cancer | AKT1,TGFB1,TCF7,SMAD2,PIK3R1,APPL1,PIK3CA,BAX,MSH6,AXIN1 |
| MicroRNAs in cancer | DDIT4,HMOX1,MMP16,PTEN,IRS2,CDC25B,DNMT1,UBE2I,MTOR,BAK1 |
| Regulation of Actin Cytoskeleton | ENAH,FGF5,MAP2K2A,ARPC5LB,FGF17,INS,ACTB,PAK2A,RHOA,LIMK1 |
| Hippo signaling pathway | JUB,MOB1A,BMPR1B,WNT9A,GDF5,PPP2R2B,WNT8B,YWHAH,CRB2,WNT16 |
| Pathways in cancer | NFKB1,GNG13,MAP2K2,TCF7,PRKACG,CBL,BCL2L1,FGF14,RBX1,WNT7A |
Protein Function
APC2 has several biochemical functions, for example, beta-catenin binding,gamma-catenin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APC2 itself. We selected most functions APC2 had, and list some proteins which have the same functions with APC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | TRPC4,TBL1X,CDH2,SMAD3,SMAD7,PTPRU,NF2,EP300,TCF7L2,CD2AP |
| gamma-catenin binding | CTNNA1,CDH1,LEF1,Fert2,FER,PTPRJ,DSG1,APC,PTBP3,PTPRK |
| microtubule binding | CKAP5,PAFAH1B1,MAP1B,NEFM,KIF17,TERF1,KIF1C,CNN3,MAP1S,KIF7 |
| protein binding | EIF2S2,SNRPA,SNF8,PIK3C3,AGPAT4,NOMO2,SNX17,SETDB1,EIF4B,MYBPC1 |
Interacting Protein
APC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APC2.
MAPRE3;TP53BP2;MAPRE1;TIMP2;YBX1
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