APBB1
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Official Full Name
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -
Overview
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the;nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1;and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent;the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of;Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by;downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different;isoforms have been described for this gene. -
Synonyms
APBB1;amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65);RIR;amyloid beta A4 precursor protein-binding family B member 1;Fe65;stat-like protein;adaptor protein FE65a2;MGC:9072
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- HEK293T
- His
- GST
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
APBB1 involved in several pathways and played different roles in them. We selected most pathways APBB1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APBB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | BID,ATP5J,PPP3CA,PLCB1,GRIN2C,ATP5E,NDUFC2-KCTD14,NDUFB1,PPP3R2,GRIN1 |
Protein Function
APBB1 has several biochemical functions, for example, beta-amyloid binding,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBB1 itself. We selected most functions APBB1 had, and list some proteins which have the same functions with APBB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| proline-rich region binding | TCERG1,FAM59A,CYLD,ABI2,WBP4,PFN1,CCND1,BAIAP2L1,PRPF40A,GAREM |
| protein binding | ERCC8,CC2D2A,E2F1,P4HA2,USP34,SLC25A46,SNRNP70,CSF2RA,DNAJB2,TNFRSF21 |
| chromatin binding | SKIL,CIC,NFKB2,STAG2,TAF2,PPARGC1A,EGFR,TCF7L1B,SLC30A9,PDX1 |
| beta-amyloid binding | BACE2,HBA-A2,CHRNA7,ARMCX5-GPRASP2,TGFB2,FBXO2,SORL1,TM2D1,APOEB,APOE |
| histone binding | PRKCB,HIST1H4F,HIST1H4M,TBL1X,HIST1H4I,ASF1A,L3MBTL1,BRD7,HIST1H3I,RCC1 |
| transcription factor binding | HDAC5,ZFPM1,HMGB2,E2F1,TFDP2,E2F4,JUND,NFKBIA,PURB,HDAC7 |
Interacting Protein
APBB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBB1.
APP;LRP1;APP;EGFR;ERBB2;CLSTN1;ANXA1;App;ATXN1
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