AOX1
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Official Full Name
aldehyde oxidase 1 -
Overview
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. -
Synonyms
AOX1;aldehyde oxidase 1;aldehyde oxidase;AO;AOH1
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- Podospora anserina (Pleurage anserina)
- Nicotiana tabacum
- Sauromatum venosum (Voodoo lily) (Typhonium venosum)
- HEK293
- Mammalian Cell
- E.Coli or Yeast
- E.coli
- Mamanlian cells
- HEK293T
- E.coli expression system
- Myc&DDK
- His
- Non
- His&Fc&Avi
- Flag
Involved Pathway
AOX1 involved in several pathways and played different roles in them. We selected most pathways AOX1 participated on our site, such as Valine, leucine and isoleucine degradation,Tyrosine metabolism,Tryptophan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | ANI_1_2390104,HADHA,CYP2F1,AOX4,RNF25,ALDH9A1A.1,TPH1A,CYP4F12,TPH1,ALDH7A1 |
| Metabolic pathways | NOS2A,TPI1A,ME1,LYCAT,PANK1B,LIPT2,ATP6V0A2,BAAT,LIPT1,HIBCH |
| Jak-STAT signaling pathway | PRL,TP-1,IL9,IFNA3,IL12RB2,PRLR,RAF1A,AOX2P,STAT5B,CNTFR |
| Valine, leucine and isoleucine degradation | ALDH2,HADHB,OXCT2A,AOX2P,ALDH6A1,ALDH9A1A.1,MCCC1,IVD,HADHAA,AUH |
| Retinol metabolism | AOX4,CYP2C37,Aldh1a7,UGT1A6B,RDH10A,CYP2A12,RDH8B,CYP2C39,CYP2B19,CYP3A7-CYP3AP1 |
| Vitamin B metabolism | PHOSPHO2,PDXK,PSAT1,AOX3,PNPO,PDXKB,AOX2P,AOX4,PDXKA,AOX3L1 |
| Tyrosine metabolism | GOT2A,TYR,HGD,ADH2-1,TH,MIF,ALDH3A1,COMTA,PNMT,ALDH3B1 |
| Nicotinate and nicotinamide metabolism | NT5C3B,ITGB1BP3,NT5C2A,NMRK2,NT5C1BA,AOX3L1,NT5C1AA,MIBP2,NADK,NMRK1 |
| Drug metabolism - cytochrome P | FMO6P,AOX3,UGT1A6,GSTM7,UGT1A2,FMO3,GSTA2,AOX2P,GSTM6,MGST3 |
Protein Function
AOX1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,NAD binding,aldehyde oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AOX1 itself. We selected most functions AOX1 had, and list some proteins which have the same functions with AOX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde oxidase activity | AOX4,AOX3L1,AOX3,ADH7 |
| molybdopterin cofactor binding | MARC2,SUOX,MARC1,XDH,MOSC2 |
| 2 iron, 2 sulfur cluster binding | AOX3L1,AIFM3,CISD2,ISCUB,FDX1B,XDH,CIAPIN1,UQCRFS1,CISD1,ISCA1 |
| xanthine dehydrogenase activity | XDH |
| NAD binding | CTBP1,IDH3B,HSD3B5,HPGD,DLD,IDH2,LDHB,AHCY,NDUFV1,MDH1 |
| oxidoreductase activity, acting on CH-OH group of donors | AOX3L1,AOX4,GULO,XDH,AGPS,AOX3,DHCR24 |
| flavin adenine dinucleotide binding | ACAD9,ACAD11,MAOA,TXNRD3,ACOX1,DUS3L,SDHA,GSR,NOX4,KMO |
| electron carrier activity | ACADL,ETFDH,DHDH,ACADSB,TXNRD1,GLRX2,GCDH,SDHC,ALDH4A1,XDH |
| iron ion binding | CYP2C55,CYP2X7,CYP2K19,BRSK2,CYP2C19,CYP2P10,CYP2X9,CYP26C1,CYP2A6,NOS2A |
Interacting Protein
AOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AOX1.
RBL1;GK;CRKL;RCHY1
AOX1 Related Signal Pathway
Resources
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References
- Kim, S; Warburton, S; et al. Regulation of alcohol oxidase 1 (AOX1) promoter and peroxisome biogenesis in different fermentation processes in Pichia pastoris. JOURNAL OF BIOTECHNOLOGY 166:174-181(2013).
- Tu, YB; Wang, YQ; et al. High-level expression and immunogenicity of a porcine circovirus type 2 capsid protein through codon optimization in Pichia pastoris. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 97:2867-2875(2013).
