AOC2
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Official Full Name
amine oxidase, copper containing 2 (retina-specific) -
Overview
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. -
Synonyms
AOC2;amine oxidase, copper containing 2 (retina-specific);retina-specific copper amine oxidase;DAO2;RAO;Amine oxidase [copper containing];Amine oxidase copper containing 2 (retina specific);Amine oxidase copper containing 2;Retina specific copper amine oxidase;SSAO;semicarbazide-sensitive amine oxidase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- Non
- Myc&DDK
- His&Myc
- His&Fc&Avi
- Flag
Involved Pathway
AOC2 involved in several pathways and played different roles in them. We selected most pathways AOC2 participated on our site, such as Glycine, serine and threonine metabolism,Tyrosine metabolism,Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tyrosine metabolism | TYR,GOT1,TH,HPDB,HPDA,AOX1,GOT2B,GOT2A,DCT,ALDH3B1 |
| Phenylalanine metabolism | TAT,ALDH3B2,MAOA,AOC3,MAOB,GOT2B,GOT1,HPDA,IL4I1,GOT2 |
| Glycine, serine and threonine metabolism | GLDC,CBSB,AGXTA,DAO.1,MAOB,AGXT,ALAS1,SRR,PGAM1A,SHMT2 |
| Metabolic pathways | PMVK,TKTB,ACAA1,REV3L,PCYT1BA,CYP2B19,SPTLC2,B3GNT2,PIK3C3,CYP3A7-CYP3AP1 |
| beta-Alanine metabolism | DPYDB,ALDH2.1,GAD1B,ACADM,HADHAA,ALDH9A1,ALDH3A1,UPB1,SRM,ALDH9A1B |
Protein Function
AOC2 has several biochemical functions, for example, aliphatic-amine oxidase activity,aminoacetone:oxygen oxidoreductase(deaminating) activity,copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AOC2 itself. We selected most functions AOC2 had, and list some proteins which have the same functions with AOC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| primary amine oxidase activity | MAOA,MAOB,AOC3,VCAM1,ABP1,AOC1 |
| copper ion binding | SOD3A,TP53,COMMD1,ABP1,COX11,HIST2H3A,SCO2,SLC11A2,HAMP,AOC1 |
| aliphatic-amine oxidase activity | AOC3 |
| electron carrier activity | PRKRA,AKR1C4,FDX1B,MAOB,AOX3,ME2,GLRX5,GLRX2,FDX1L,CYP1A2 |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | AOC3 |
| aminoacetone:oxygen oxidoreductase(deaminating) activity | AOC3 |
| quinone binding | AOC1,SQRDL,NDUFS7,HHIPL1,HHIPL2,ETFDH,VKORC1L1,AOC3,HHIP,CBR4 |
| tryptamine:oxygen oxidoreductase (deaminating) activity | AOC3 |
Interacting Protein
AOC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AOC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AOC2.
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References
- Imamura, Y; Kubota, R; et al. Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping. GENOMICS 40:277-283(1997).
