ANO2
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Official Full Name
anoctamin 2 -
Overview
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 (PubMed;19015192)). -
Synonyms
ANO2;anoctamin 2;C12orf3, chromosome 12 open reading frame 3 , TMEM16B, transmembrane protein 16B;anoctamin-2;transmembrane protein 16B (eight membrane spanning domains);transmembrane protein 16B (eight membrane-spanning domains);C12orf3;TMEM16B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANO2-1698M | Recombinant Mouse ANO2 Protein | Mammalian Cell | Mouse | His |
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| ANO2-6154Z | Recombinant Zebrafish ANO2 | Mammalian Cell | Zebrafish | His |
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| ANO2-8014H | Recombinant Human ANO2 protein, His & T7-tagged | E.coli | Human | His&T7 | Ala823~Val1003 |
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| Ano2-157M | Recombinant Mouse Ano2 Protein, His-tagged | E.coli | Mouse | His | Lys644-Met747 |
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| ANO2-568M | Recombinant Mouse ANO2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ANO2-568M-B | Recombinant Mouse ANO2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ANO2 involved in several pathways and played different roles in them. We selected most pathways ANO2 participated on our site, such as Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Olfactory transduction | OLFR181,PRKACA,OLFR998,OLFR498,OR10J1,OR2B3,OR2A4,CAMK2G,OLFR507,OLFR491 |
Protein Function
ANO2 has several biochemical functions, for example, chloride channel activity,intracellular calcium activated chloride channel activity,NOT phospholipid scramblase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO2 itself. We selected most functions ANO2 had, and list some proteins which have the same functions with ANO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular calcium activated chloride channel activity | CLCA1,CLCA2,NMUR2,ANO8,TTYH3,ANO7,CLCA4,ANO4,ANO9,ANO6 |
| protein heterodimerization activity | BCL2L10,RALGAPA1,MYO5A,NR2C2,HIST1H2BN,MYH7,CD3D,MYOG,BOKB,SLC3A1 |
| protein homodimerization activity | NCR3,DPY30,STUB1,GIPC1,NOS1,SLC11A1,VPS25,BMPR1A,BNIP3,GDNF |
| chloride channel activity | CLCA2,GABRE,GABRP,CLCN5,CLCN7,CLCN4,CLIC5B,CLCA1,FXYD1,GRAP2 |
| NOT phospholipid scramblase activity | ANO5,ANO10 |
| protein binding | ENC1,OSBPL7,CTDP1,ARR3,CCT8,LOX,TSC2,THOC1,OTOF,EPB41L1 |
Interacting Protein
ANO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO2.
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References
- Gonzalez-Silva, C; Vera, J; et al. Ca2+-Activated Cl- Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons. PLOS ONE 8:-(2013).
- Sotriffer, CA; Flader, W; et al. Automated docking of ligands to antibodies: Methods and applications. METHODS 20:280-291(2000).
