ANK2
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Official Full Name
Ankyrin 2, Neuronal -
Overview
Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. -
Synonyms
ANK2;ankyrin 2, neuronal;LQT4;ANK-2;brank-2;ankyrin-2;ankyrin B;ankyrin, brain;non-erythroid ankyrin;ankyrin-2, non-erythrocytic;Brain ankyrin;long (electrocardiographic) QT syn-drome 4;DKFZp686M09125;FLJ38277;OTTHUMP00000163833;OTTHUMP00000163834;OTTHUMP00000220392;OTTHUMP00000220393;OTTHUMP00000220397;OTTHUMP00000220398;OTTHUMP00000231464;ankyrin, nonerythroid;Ankyrin-B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANK2-1645M | Recombinant Mouse ANK2 Protein | Mammalian Cell | Mouse | His |
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| ANK2-103H | Recombinant Human ANK2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| ANK2-2077H | Recombinant Human ANK2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Ank2-429M | Recombinant Mouse Ank2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ANK2-533M | Recombinant Mouse ANK2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ANK2-533M-B | Recombinant Mouse ANK2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ANK2 involved in several pathways and played different roles in them. We selected most pathways ANK2 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | ARHGEF1,PIK3CG,MAPK3,WNT5A,SMAD2,TLR2,CAV3,CAV2,PIK3R3,WNT3A |
Protein Function
ANK2 has several biochemical functions, for example, ATPase binding,ion channel binding,potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANK2 itself. We selected most functions ANK2 had, and list some proteins which have the same functions with ANK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase binding | FXYD3,NOP58,ATP6V1E1,SNTA1,ATP1B3,GRIN2A,NHP2L1,ABCA1,SYVN1,SLC26A9 |
| protein binding | NINJ2,SNX27,TOLLIP,RAB32,SERTAD1,IP6K2,TERF2IP,RAB34,ADAM10,SOCS1 |
| protein binding, bridging | RAD50,STUB1,TRIM5,FSCN2B,AMFR,TJP2,NUFIP1,NEFL,WWC1,COL8A2 |
| potassium channel regulator activity | KCNIP4,AKAP9,DLG1,ARPP19A,NEDD4L,KCNV1,ARPP19,KCNE1,SGK2A,SGK2B |
| ion channel binding | PIRT,ABCC9,PKD1,DIAPH1,KCNIP1,SLC14A2,PKP2,SRI,GRINA,SCN3B |
Interacting Protein
ANK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANK2.
Sptan1;Kif3a;SNCA;Ywhae;Ywhaz;Kifap3;Ywhab;Actg1;Dctn4
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