ANAPC2
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Official Full Name
anaphase promoting complex subunit 2 -
Overview
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. -
Synonyms
ANAPC2;anaphase promoting complex subunit 2;APC2;RP11-350O14.5;Anaphase-promoting complex subunit 2;Cyclosome subunit 2;KIAA1406;OTHUMP00000022692
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
ANAPC2 involved in several pathways and played different roles in them. We selected most pathways ANAPC2 participated on our site, such as Cell cycle,Oocyte meiosis,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Progesterone-mediated oocyte maturation | MOS,RAF1A,GNAI3,PIK3R3A,CDC16,GNAI2A,PRKACA,MAPK14A,RPS6KA2,PIK3CD |
| HTLV-I infection | HLA-C,AKT2,CCNB2,PDGFRB,ANAPC1,ANAPC4,TCF3,ZFP36,KAT2B,TGFB3 |
| Cell cycle | SSNA1,SYCP2,ESCO1,TGFB1A,CDCA8,TUBGCP4,TOP2A,SMAD3,DPF1,RAD21B |
| Ubiquitin mediated proteolysis | UBE2NB,MAP3K1,CUL1B,UBE2E3,UBE2G1A,UBE2E1,CUL3B,CDC23,ANAPC13,CDC27 |
| Oocyte meiosis | FBXW11B,YWHAQA,ANAPC13,PPP1CB,FBXW11,YWHAG1,CALM4,PLCZ1,MAPK1,PPP3CCA |
Protein Function
ANAPC2 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC2 itself. We selected most functions ANAPC2 had, and list some proteins which have the same functions with ANAPC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | MUL1,NKD2,EGR2,UCHL1,SCN5A,CUL4A,CDC34B,TRAF4,RB1,PIAS2 |
| contributes_to ubiquitin protein ligase activity | FBXL15,CUL2,FBXL7,C10orf46,CUL5A,KDM2BA,SKP2,CUL1,FBXL3B,MED11 |
Interacting Protein
ANAPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC2.
Cdc23;Cdc16;Cdc26;Cdc20;CDC27;CDC16;CDC23;MAGEB2
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References
- Niu, YD; Wang, ZL; et al. Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest. CANCER LETTERS 347:88-97(2014).
- Shoji, S; Muto, Y; et al. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS OPEN BIO 4:689-703(2014).
