AMN
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Official Full Name
amnionless homolog (mouse) -
Overview
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. -
Synonyms
AMN;amnionless homolog (mouse);protein amnionless;visceral endoderm-specific type 1 transmembrane protein;PRO1028
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Mammalian cells
- Mammalian Cell
- E.coli
- E. coli
- HEK293T
- HEK293
- His
- N-His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AMN-777H |
Active Recombinant Human AMN Protein, His-tagged
|
Mammalian cells | Human | His | Val20-Ala358 |
|
| AMN-4907C | Recombinant Chicken AMN | Mammalian Cell | Chicken | His |
|
|
| AMN-7084H | Recombinant Human AMN, His-tagged | E.coli | Human | His | 20-357aa |
|
| AMN-768H | Recombinant Human AMN | Mammalian Cell | Human | His |
|
|
| ADAMTS18-2423H | Recombinant Human ADAMTS18 protein, His-tagged | E. coli | Human | N-His | 949-1116 aa |
|
| Amn-136R | Recombinant Rat Amn Protein, His-tagged | E.coli | Rat | His | Ala20-Glu268 |
|
| Amn-1612M | Recombinant Mouse Amn Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| AMN-1987H | Recombinant Human AMN Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| AMN-2462H | Recombinant Human AMN Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| AMN-2462H-B | Recombinant Human AMN Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
Involved Pathway
AMN involved in several pathways and played different roles in them. We selected most pathways AMN participated on our site, such as Cobalamin (Cbl, vitamin B12) transport and metabolism,Defective AMN causes hereditary megaloblastic anemia 1,Defective CUBN causes hereditary megaloblastic anemia 1, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Disease | CCDC59,CHMP4C,PDCD6IP,STRA6,TLR10,NMT1,CUX1,HEYL,ARF1,AP2M1 |
| HDL-mediated lipid transport | Alb,APOA1B,ABCA1,CETP,APOC2,BMP1A |
| Defects in cobalamin (B12) metabolism | MTRR,MMAA,MMADHC |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | MMADHC,ELA2L,TCN1,ELA2,CD320,MMAA,LOC100686744,CTRC,CBLC-1,MTRR |
| Diseases of metabolism | FDXR,FDX1,SFTPC,GYG1,SFTPB,EPM2A,MMAA,FDX1L,CCDC59,CYP11A1 |
| Defects in vitamin and cofactor metabolism | MMADHC,MMAA,MTRR |
Protein Function
AMN has several biochemical functions, for example, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMN itself. We selected most functions AMN had, and list some proteins which have the same functions with AMN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | DAO,EFNA1,GRP,CTNND1,FGF24,FGG,WNT7AA,HNF4A,PRDX5,TYROBP |
Interacting Protein
AMN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMN here. Most of them are supplied by our site. Hope this information will be useful for your research of AMN.
Resources
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References
- Storm, T; Zeitz, C; et al. Detailed investigations of proximal tubular function in Imerslund-Grasbeck syndrome. BMC MEDICAL GENETICS 14:-(2013).
- Christensen, EI; Nielsen, R; et al. From bowel to kidneys: the role of cubilin in physiology and disease. NEPHROLOGY DIALYSIS TRANSPLANTATION 28:274-281(2013).
