Alox8
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Official Full Name
arachidonate 8-lipoxygenase -
Synonyms
ALOX8;arachidonate 8-lipoxygenase;ENSMUSG00000020891;8-LOX;8S-LOX;Alox15b;11;11 B4;arachidonate 15-lipoxygenase B;arachidonate 15-lipoxygenase B;15-LOX-2;15-LOX-B;8S-lipoxygenase;15-lipoxygenase 2;arachidonate 15-lipoxygenase type II;arachidonate 15-lipoxygenase, second type;EC 1.13.11.33
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALOX8-1569M | Recombinant Mouse ALOX8 Protein | Mammalian Cell | Mouse | His |
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| ALOX8-485M | Recombinant Mouse ALOX8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ALOX8-485M-B | Recombinant Mouse ALOX8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
Alox8 involved in several pathways and played different roles in them. We selected most pathways Alox8 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP2J6,CYP4T8,CYP1A1,PTGES3B,ALOX12B,PTGS2B,CYP4F3,PLA2G12B,ALOX5A,CYP2C39 |
| Serotonergic synapse | PRKACB,HTR1E,HTR6,HTR2A,MAPK1,CYP2C39,RAF1,SLC18A2,SLC18A1,CYP4X1 |
| Metabolic pathways | ATP5IB,MTHFD1B,NDUFB10,AGMAT,POLR1B,PDHB,ST8SIA5,GBA3,DAK,PNMT |
Protein Function
Alox8 has several biochemical functions, for example, 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity,1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity,1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox8 itself. We selected most functions Alox8 had, and list some proteins which have the same functions with Alox8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity | UOX,MOSC2,MOXD1L,HADHAB,PYCR1A,HSD3B6,CYP2J5,CYP2A12,CYP2C50,RNLS |
| lipid binding | PFN3,DLC1,APOC2,APOEA,BAX,APOE,EPN2,APOL2,PLEKHA2,PAQR5B |
| dioxygenase activity | JMJD1C,TDO2A,ALKBH7,KDM5D,PHYHD1,ALOX5A,PHF2,ALKBH6,KDM3A,ASPHD1 |
| linoleate 13S-lipoxygenase activity | ALOX12,ALOX15B |
| arachidonate 8(S)-lipoxygenase activity | ALOX15B |
| calcium ion binding | PLCD3A,EFEMP1,PCDH1,CD248,CELSR1,CALB2A,EHD2B,RCV1,TNNC2,GUCA1E |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | P4HA2,ALOX5B.2,P4HA1,BCO2,ALOX12,P4HA3,P4HA1B,TMLHE,ADOB,ALOX12E |
| arachidonate 15-lipoxygenase activity | ALOX15,ALOX15B |
| iron ion binding | MTRR,CYP2E1,SC5DL,ALKBH8,HBBE1.1,CYP4A12A,CYP4A14,P4HA1B,CYP2C9,CYP2B19 |
Interacting Protein
Alox8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox8.
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References
- Kawajiri, H; Piao, YS; et al. Synthesis of 8,9-leukotriene A(4) by murine 8-lipoxygenase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338:144-148(2005).
- Furstenberger, G; Marks, F; et al. Arachidonate 8(S)-lipoxygenase. PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9:235-243(2002).
