ALKBH8
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Official Full Name
alkB, alkylation repair homolog 8 -
Synonyms
ALKBH8;alkB, alkylation repair homolog 8 (E. coli);alkylated DNA repair protein alkB homolog 8;MGC10235;AlkB homologue 8;probable alpha-ketoglutarate-dependent dioxygenase ABH8;tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8;S-adenosyl-L
Recombinant Proteins
- Mouse
- Bovine
- Human
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- Non
- N-His
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ALKBH8 involved in several pathways and played different roles in them. We selected most pathways ALKBH8 participated on our site, such as Gene Expression,tRNA modification in the nucleus and cytosol,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA modification in the nucleus and cytosol | PUS1,ADAT3,TRMT12,THG1L,TRMT11,TYW1,NSUN2,ADAT2,MANEA,METTL1 |
| tRNA processing | THG1L,RPP40,PUS7,PUS1,TRMT61A,POP1,QTRTD1,TRMT6,TRMT12,TSEN54 |
| Gene Expression | SMARCA5,SAP30BP,ZNF10,ZNF143,ZCRB1,ZNF136,ZFP90,TSEN34,RPP14,CHD4 |
Protein Function
ALKBH8 has several biochemical functions, for example, iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH8 itself. We selected most functions ALKBH8 had, and list some proteins which have the same functions with ALKBH8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LIN37,POMP,P2RY1,POC1B,FOXK1,MYF5,CD1d1,SUZ12,ARAP3,UBXN11 |
| tRNA (uracil) methyltransferase activity | RNMTL1A,METTL23,TRMT44,FBLL1,METTL8,METTL21D,DIMT1,PRMT8B,PRDM12,NDUFAF5 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | C14orf169,P4HTM,EGLN2,EGLN3,ALKBH4,TYW5,HIF1AN,KDM5BA,KDM5D,KDM5BB |
| iron ion binding | CYP1D1,MSMO1,TMLHE,CYP2B19,CYP19A1,TH2,CYP7A1A,EGLN1B,CYP2AA2,CYP46A1.4 |
| tRNA binding | XPOT,TRNT1,IGHMBP2,FARSA,CTU1,RPL35A,MARS,AIMP1,IFIT5,FARS2 |
| zinc ion binding | TAF2,ZFAND3,FBXO30,ZNRF4,ZCCHC11,CAD,BTR22,SIVA1,UBR3,LMCD1 |
Interacting Protein
ALKBH8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH8.
TRMT112;HSP90AA1;CCNB1;TCP1;CCT6A;CCT5;CCT8;CCT4;CCT2;q59h77_human
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