ALKBH4
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Official Full Name
alkB, alkylation repair homolog 4 (E. coli) -
Synonyms
ALKBH4;alkB, alkylation repair homolog 4 (E. coli);21900;ENSG00000160993;ABH4;7q22.1;FLJ20013;probable alpha-ketoglutarate-dependent dioxygenase ABH4;probable alpha-ketoglutarate-dependent dioxygenase ABH4;alkylated DNA repair protein alkB homolog 4
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- Wheat Germ
- E. coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- N-His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALKBH4-1556M | Recombinant Mouse ALKBH4 Protein | Mammalian Cell | Mouse | His |
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| ALKBH4-307R | Recombinant Rhesus monkey ALKBH4 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ALKBH4-476H | Recombinant Human ALKBH4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ADAM15-2422H | Recombinant Human ADAM15 protein, His-tagged | E. coli | Human | N-His | 500-660 aa |
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| ALKBH4-135R | Recombinant Rhesus Macaque ALKBH4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ALKBH4-135R-B | Recombinant Rhesus Macaque ALKBH4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ALKBH4-1448HF | Recombinant Full Length Human ALKBH4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 302 amino acids |
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| ALKBH4-476M | Recombinant Mouse ALKBH4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ALKBH4-476M-B | Recombinant Mouse ALKBH4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ALKBH4 involved in several pathways and played different roles in them. We selected most pathways ALKBH4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ALKBH4 has several biochemical functions, for example, actin binding,demethylase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH4 itself. We selected most functions ALKBH4 had, and list some proteins which have the same functions with ALKBH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | TMOD3,SMYHC1,STK38L,ITGB1,MYO5C,MYH6,MYH13,MYH1,WASH1,VPS18 |
| protein binding | SCLY,NKX3,CD86,TFDP2,VPS8,USH1G,CKM,TNNI2,DHX58,PAXIP1 |
| metal ion binding | MFI2,PAK3,RNF11A,SP5A,HGD,ZNF697,RACGAP1,B3GAT3,PRKCDA,MT2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | KDM5B,P4HTM,KDM5A,EGLN2,TYW5,HIF1AN,PHF8,EGLN3,KDM5D,JHDM1D |
| demethylase activity | CYP3A41B,CYP1A1,CYP1A2,KDM1A,CYP3A41A |
Interacting Protein
ALKBH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH4.
DTX2;DTX2;TRAF4
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References
- Nilsen, A; Fusser, M; et al. ALKBH4 Depletion in Mice Leads to Spermatogenic Defects. PLOS ONE 9:-(2014).
- Li, MM; Nilsen, A; et al. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. NATURE COMMUNICATIONS 4:-(2013).
