ALG8
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Official Full Name
asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) -
Overview
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of;the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins.;Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively;spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ALG8;asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae);asparagine linked glycosylation 8 homolog (yeast, alpha 1,3 glucosyltransferase);probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase;MGC2840;3-glucosyltransferase;AI447372;ALG 8;ALG8_HUMAN;Asparagine linked glycosylation 8 alpha 1,3 glucosyltransferase homolog;Asparagine linked glycosylation 8 homologyeast, alpha 1,3 glucosyltransferase;Asparagine linked glycosylation 8 homolog S. cerevisiae, alpha 1,3 glucosyltransferase;Asparagine-linked glycosylation protein 8 homolog;CDG1H;Dolichyl P Glc Glc1Man9GlcNAc2 PP dolichyl glucosyltransferase;Dolichyl P glucose Glc1Man9GlcNAc2 PP dolichyl alpha 1,3 glucosyltransferase;Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase;Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase;Gm1089;HUSSY 02;MGC74399;Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase;Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1;HUSSY-02;dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase;dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase;dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl-alpha-1,3-glucosyltransferase;asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase);asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Pseudomonas Putida
- Pseudomonas Syringae Pv. Tomato
- Pseudomonas aeruginosa
- Azotobacter vinelandii
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
ALG8 involved in several pathways and played different roles in them. We selected most pathways ALG8 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| N-Glycan biosynthesis | MGAT1,MGAT4C,ST6GAL1,DOLK,ALG10,ZNF408,MGAT5B,ALG12,DOLPP1,MGAT1A |
| Metabolic pathways | UGP2,CYP3A65,TDO2B,GALK1,DCTPP1,ETNK1,DGKAA,ENO1A,HPSE2,ASAH1 |
Protein Function
ALG8 has several biochemical functions, for example, alpha-1,3-mannosyltransferase activity,dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG8 itself. We selected most functions ALG8 had, and list some proteins which have the same functions with ALG8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-1,3-mannosyltransferase activity | ALG2,GTDC2,B3GNTL1,UGGT1,B3GNT9-PS,GLT8D1,PIGB,GALNT18A,POC1BL,POMGNT2 |
| dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity | DPY19L1,GTDC2,ALG6,B3GNTL1,B3GNT9-PS,UGGT1,PIGB,GLT8D1,DPY19L4,GALNT18A |
Interacting Protein
ALG8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG8.
RPS6KA5;NAE1;Atp2a2
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