ALG14
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Official Full Name
ALG14 asparagine-linked glycosylation 14 homolog (S. cerevisiae) [ Homo sapiens ] -
Overview
Asparagine (N)-glycosylation is an essential modification that regulates protein folding and stability. ALG13 and ALG14 (MIM 612866) constitute the UDP-GlcNAc transferase, which catalyzes a key step in endoplasmic reticulum N-linked glycosylation (Averbeck et al., 2007 [PubMed 17686769]). -
Synonyms
asparagine-linked glycosylation 14 homolog (S. cerevisiae);MGC19780;asparagine-linked glycosylation 14 homolog (yeast);UDP-N-acetylglucosamine transferase subunit ALG14 homolog;ALG14
Recombinant Proteins
- Mouse
- Zebrafish
- Rat
- Human
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALG14-1545M | Recombinant Mouse ALG14 Protein | Mammalian Cell | Mouse | His |
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| ALG14-1598Z | Recombinant Zebrafish ALG14 | Mammalian Cell | Zebrafish | His |
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| ALG14-629R | Recombinant Rat ALG14 Protein | Mammalian Cell | Rat | His |
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| ALG14-8907HCL | Recombinant Human ALG14 293 Cell Lysate | HEK293 | Human | Non |
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| ALG14-285R | Recombinant Rat ALG14 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ALG14-285R-B | Recombinant Rat ALG14 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ALG14-465M | Recombinant Mouse ALG14 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ALG14-465M-B | Recombinant Mouse ALG14 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ALG14 involved in several pathways and played different roles in them. We selected most pathways ALG14 participated on our site, such as Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | IGF2B,ALG2,EXOC6,CST3,DAD1,SFTPBB,KIFC3,IGFALS,INHBAA,PPP6R1 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | SLC35A1,NEU3,ST6GALNAC2,ALG10B,ST8SIA3,ST6GAL2B,DPAGT1,MPDU1B,NEU4,NANP |
| N-Glycan biosynthesis | DPAGT1,MGAT5B,DPM3,RPN1,ZNF408,DOLPP1,GANAB,STT3A,ALG12,ALG10B |
| Metabolic pathways | KHK,DAO.1,UCK2B,LIAS,ATP6V1G2,ACLY,QDPRB1,CYP1A,CYP2C18,GALE |
| Asparagine N-linked glycosylation | PPP6R3,CNIH3,DDOST,MLEC,NEU4,SEC22C,MCFD2,TRAPPC3,TMED10,TRAPPC6A |
| Post-translational protein modification | NANP,MUCL1,OTOP2,SMC6,GALNTL5,SUMF2,ADAMTSL1,ARSJ,MUC15,ST6GAL2B |
Protein Function
ALG14 has several biochemical functions, for example, contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity,protein anchor. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG14 itself. We selected most functions ALG14 had, and list some proteins which have the same functions with ALG14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein anchor | RAPSN,SUN5,SUN1,MYH9,AKAP6,CIB1,PDCD6,SUN3,NUP153,SLC4A1 |
Interacting Protein
ALG14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG14 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG14.
Resources
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References
- Monies, DM; Al-Hindi, HN; et al. Clinical and pathological heterogeneity of a congenital disorder of glycosylation manifesting as a myasthenic/myopathic syndrome. NEUROMUSCULAR DISORDERS 24:353-359(2014).
- Wu, JHY; Lemaitre, RN; et al. Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway Results From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. CIRCULATION-CARDIOVASCULAR GENETICS 6:171-+(2013).
