ALDH9A1

  • Official Full Name

    aldehyde dehydrogenase 9 family, member A1

  • Overview

    This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.

  • Synonyms

    ALDH9A1;aldehyde dehydrogenase 9 family, member A1;ALDH4, ALDH7, ALDH9;4-trimethylaminobutyraldehyde dehydrogenase;E3;4 trimethylaminobutyraldehyde dehydrogenase;AL9A1_HUMAN;aldehyde dehydrogenase (NAD+);Aldehyde dehydrogenase 9A1;Aldehyde dehydrogenase E3 isozyme;Aldehyde dehydrogenase family 9 member A1;ALDH4;ALDH7;ALDH9;Gamma aminobutyraldehyde dehydrogenase;Gamma-aminobutyraldehyde dehydrogenase;R aminobutyraldehyde dehydrogenase;R-aminobutyraldehyde dehydrogenase;TMABADH;OTTHUMP00000032604

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • In Vitro Cell Free System
  • HEK293T
  • HEK293
  • His
  • His&T7
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ALDH9A1-3945H Recombinant Human ALDH9A1 protein, His-tagged E.coli Human His 285-412 aa
Aldh9a1-1360M Recombinant Mouse Aldh9a1 protein, His & T7-tagged E.coli Mouse His&T7 Leu322~Phe494
ALDH9A1-454H Recombinant Human ALDH9A1 Protein, GST-tagged Wheat Germ Human GST
ALDH9A1-624R Recombinant Rat ALDH9A1 Protein Mammalian Cell Rat His
ALDH9A1-61HCL Recombinant Human ALDH9A1 cell lysate Human Non
ALDH9A1-1418HF Recombinant Full Length Human ALDH9A1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 494 amino acids
Aldh9a1-1595M Recombinant Mouse Aldh9a1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
ALDH9A1-280R Recombinant Rat ALDH9A1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ALDH9A1-280R-B Recombinant Rat ALDH9A1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ALDH9A1-6469H Recombinant Human ALDH9A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    ALDH9A1 involved in several pathways and played different roles in them. We selected most pathways ALDH9A1 participated on our site, such as Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis TPI1,PCK1,PKLR,G6PCA.2,AKR1A1B,PGAM2,MINPP1A,ALDOAB,LDHAL6A,PGM1
    Histidine metabolism ALDH3A1,HDC,ALDH3A2,ABP1,ALDH1A3,CNDP1,HNMT,AMDHD1,ALDH2,ALDH2.2
    beta-Alanine metabolism ALDH3A2A,CNDP2,ALDH1B1,ALDH9A1A.1,ALDH9A1B,ALDH2,ALDH3B2,DPYDB,ALDH6A1,ALDH2.2
    Arginine and proline metabolism CARNS1,SMS,CKB,CKMT1,GOT2,AZIN2,DAO.1,AOC1,ALDH1B1,PYCR2
    Metabolic pathways GAMT,NDUFA11,TYMS,HPRT1,GPIB,MTHFS,IMPAD1,DPYD,UGT1A7C,MIBP2
    Valine, leucine and isoleucine degradation ALDH3A2,ACSF3,ACAA1,HIBADH,ALDH2,MCCC1,OXCT2A,HMGCL,HADHB,ACADSB
    Glycerolipid metabolism MBOAT1,GLA,LPIN1,glpK,PNLIP,AKR1A1B,GPAT2,GLYCTK,DGAT2,ALDH3A2
    Fatty acid degradation ACAT1,HADHA,ALDH2,ECI1,ADH2-2,ECI2,ADH1A,CYP4A11,ACADM,ALDH2.2
    Pyruvate metabolism PKMA,PDHA1,LDHA,MDH1AA,LDHB,LDHC,ALDH3A2A,DLAT,ackA,HAGHL

    Protein Function

    ALDH9A1 has several biochemical functions, for example, 1-pyrroline dehydrogenase activity,3-chloroallyl aldehyde dehydrogenase activity,4-trimethylammoniobutyraldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH9A1 itself. We selected most functions ALDH9A1 had, and list some proteins which have the same functions with ALDH9A1. You can find most of the proteins on our site.

    Function Related Protein
    aminobutyraldehyde dehydrogenase activity ALDH9A1B,ALDH9A1A.1
    aldehyde dehydrogenase (NAD) activity ALDH9A1B,ALDH1A3,ALDH3A1,ALDH1L1,ALDH3B2,ALDH2,ALDH1A1,ALDH7A1,ALDH8A1,ALDH9A1A.1
    4-trimethylammoniobutyraldehyde dehydrogenase activity ALDH9A1A.1,ALDH9A1B
    3-chloroallyl aldehyde dehydrogenase activity Aldh1a7,ALDH3A1,ALDH3A2B,ALDH3B2,ALDH3A2A,ALDH3A2,ALDH2.1,ALDH3B1,ALDH1A1

    Interacting Protein

    ALDH9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH9A1.

    HLA-B;USP46;TNIP3;DDA1;flgH1;GABARAPL1

    Resources

    References

    • Yang, Y; Zhou, W; et al. NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma. ONCOTARGET 5:11986-11997(2014).
    • Li, XS; Xu, Q; et al. ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer. BMC CANCER 14:-(2014).

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