ALDH4A1
-
Official Full Name
aldehyde dehydrogenase 4 family, member A1 -
Overview
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
ALDH4A1;aldehyde dehydrogenase 4 family, member A1;ALDH4;delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial;P5CDh;P5C dehydrogenase;aldehyde dehydrogenase family 4 member A1;mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase;P5C
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Chicken
- Mammalian Cell
- Wheat Germ
- Insect Cells
- E.coli
- Insect Cell
- In Vitro Cell Free System
- HEK293T
- HEK293
- Mammalian cells
- His
- GST
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
ALDH4A1 involved in several pathways and played different roles in them. We selected most pathways ALDH4A1 participated on our site, such as Alanine, aspartate and glutamate metabolism,Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CES1,ACSS2L,PDHA1,PRIM2,POC1BL,GALNTL4,GALNT5,SDHDB,CKMT1,PGAM1 |
| Arginine and proline metabolism | AGMAT,P4HA2,SAT2,ARG1,MAOB,NOS3,P4HA3,DAO,PRODH2,OAT |
| Alanine, aspartate and glutamate metabolism | ASNS,IL4I1,AGXTB,GAD1,ADSS,ABAT,ASS1,GAD2,GLS,ASL |
Protein Function
ALDH4A1 has several biochemical functions, for example, 1-pyrroline-5-carboxylate dehydrogenase activity,aldehyde dehydrogenase (NAD) activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH4A1 itself. We selected most functions ALDH4A1 had, and list some proteins which have the same functions with ALDH4A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | GCDH,GRXCR1,GLRX3,POR,NDUFS1,ACADSB,QDPR,CYP19A1,ME1,UQCR11 |
| identical protein binding | APLP2,MCM6,EDC3,GUCY2E,CLDN4,NELL2,KHDRBS1,BCAT1,PTK6,PON2 |
| aldehyde dehydrogenase (NAD) activity | ALDH7A1,ALDH3A1,ALDH8A1,ALDH9A1B,ALDH3A2B,ALDH6A1,ALDH1B1,ALDH1L2,ALDH9A1,ALDH3B2 |
Interacting Protein
ALDH4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH4A1.
ARG1;CLPP
Resources
Related Services
Related Products
References
- Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).
- Ueyama, T; Yamamoto, Y; et al. Is Gastrectomy-Induced High Turnover of Bone with Hyperosteoidosis and Increase of Mineralization a Typical Osteomalacia?. PLOS ONE 8:-(2013).
