ALDH3B1
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Official Full Name
aldehyde dehydrogenase 3 family, member B1 -
Overview
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene is highly expressed in kidney and lung. The functional significance of this gene as well as the cellular localization of its product are presently unknown. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ALDH3B1;aldehyde dehydrogenase 3 family, member B1;ALDH7;aldehyde dehydrogenase family 3 member B1;aldehyde dehydrogenase 3B1;aldehyde dehydrogenase 7;ALDH4;FLJ26433;FLJ34710
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALDH3B1-447H | Recombinant Human ALDH3B1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALDH3B1-622R | Recombinant Rat ALDH3B1 Protein | Mammalian Cell | Rat | His |
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| ALDH3B1-9495Z | Recombinant Zebrafish ALDH3B1 | Mammalian Cell | Zebrafish | His |
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| ALDH3B1-58HCL | Recombinant Human ALDH3B1 cell lysate | Human | Non |
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| ALDH3B1-118H | Recombinant Human ALDH3B1 Protein, His-tagged | E.coli | Human | His | Met1-Glu459 |
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| Aldh3b1-119M | Recombinant Mouse Aldh3b1 Protein, His-tagged | E.coli | Mouse | His | Met1-Cys465 |
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| ALDH3B1-1407HF | Recombinant Full Length Human ALDH3B1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 468 amino acids |
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| ALDH3B1-278R | Recombinant Rat ALDH3B1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ALDH3B1-278R-B | Recombinant Rat ALDH3B1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
ALDH3B1 involved in several pathways and played different roles in them. We selected most pathways ALDH3B1 participated on our site, such as Glycolysis / Gluconeogenesis,Histidine metabolism,Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH3B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | UGT1A9,MGST2,CYP3A4,ALDH1A3,FAM84B,ALDH3A1,SULT1A1,CYP3A7-CYP3AP1,CYP2A6,ADH7 |
| Drug metabolism - cytochrome P | AOX3,AOX3L1,MGST3,FMO2,GSTA1,GSTA,UGT1A6B,MGST1.2,UGT2B7,MGST1.1 |
| beta-Alanine metabolism | CARNS1,HADHAA,ALDH3A1,AOC2,UPB1,ALDH6A1,SMOX,GAD1B,ALDH1A3,ALDH3B2 |
| Glycolysis / Gluconeogenesis | GAPDHS,ALDH9A1B,ALDH9A1A.1,ENO2,PFKMB,ADH6,PFKL,PKMA,ADH2-1,PKM |
| Tyrosine metabolism | AOX3L1,TYRP1,MAOB,ALDH1A3,ALDH3A1,GOT2A,TH,TYR,AOX1,ADH2-2 |
| Metabolism of xenobiotics by cytochrome P | GSTA5,GSTM3,GSTT1B,GSTT1,AKR7A3,ALDH3A1,CBR1,UGT1A9,MGST2,GSTT2 |
| Phenylalanine metabolism | HPDB,AOC2,GOT2,TAT,HPDA,MAOB,ALDH1A3,AOC3,GOT2A,MIF |
| Metabolic pathways | IDO1,ACSL3A,XYLB,AK8,SUCLG1,CSAD,BCO1L,ALG8,POLR2J2,UGT1A6A |
| Histidine metabolism | FTCD,ALDH3B2,UROC1,ALDH9A1B,HAL,ALDH3A2A,ALDH9A1A.1,CARNS1,ALDH3A1,ALDH1B1 |
Protein Function
ALDH3B1 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity,aldehyde dehydrogenase [NAD(P)+] activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH3B1 itself. We selected most functions ALDH3B1 had, and list some proteins which have the same functions with ALDH3B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | APBA3,TOP1,TMEM174,TRAF2,MCEE,DNAJB2,VAMP4,CPEB4,PAM,CCDC9 |
| aldehyde dehydrogenase [NAD(P)+] activity | ALDH3A2A,ALDH3A2B,ALDH2,ALDH3A1,ALDH1A3,ALDH3B2,ALDH3A2 |
| 3-chloroallyl aldehyde dehydrogenase activity | ALDH3A2B,ALDH3A2A,ALDH2.1,ALDH3A2,ALDH3B2,Aldh1a7,ALDH1A1,ALDH3A1,ALDH9A1 |
Interacting Protein
ALDH3B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH3B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH3B1.
KRTAP10-5;KRTAP10-7;KRTAP10-8;KRTAP10-9;KRT31;KRT40
Resources
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References
- Jin, J; Krishack, P; et al. Role of aldo-keto reductases in development of prostate and breast cancer. FRONTIERS IN BIOSCIENCE 11:2767-2773(2006).
- Wilke, VL; Nettleton, D; et al. Gene expression in intestinal mucosal biopsy specimens obtained from dogs with chronic enteropathy. AMERICAN JOURNAL OF VETERINARY RESEARCH 73:1219-1229(2012).
