ALDH3A1
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Official Full Name
aldehyde dehydrogenase 3 family, member A1 -
Overview
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] -
Synonyms
ALDH3A1;aldehyde dehydrogenase 3 family, member A1;ALDH3;ALDHIII;aldehyde dehydrogenase, dimeric NADP-preferring;stomach aldehyde dehydrogenase;aldehyde dehydrogenase type III;aldehyde dehydrogenase isozyme 3
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Insect Cells
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- Insect Cell
- Mammalian cells
- In Vitro Cell Free System
- HEK293
- HEK293T
- His
- GST
- Non
- His&Myc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ALDH3A1 involved in several pathways and played different roles in them. We selected most pathways ALDH3A1 participated on our site, such as Glycolysis / Gluconeogenesis,Histidine metabolism,Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phenylalanine metabolism | ALDH1A3,MAOB,ALDH3B2,KEG1,GOT2A,MAOA,MIF,GOT1,HPDA,GOT2B |
| Drug metabolism - cytochrome P | UGT2B15,GSTM4,MGST1.1,UGT1A7C,UGT1A7,GSTO1,MGST1,MGST3,AOX2P,UGT5G1 |
| Histidine metabolism | HAL,CARNS1,ALDH3A2,ALDH3B2,ALDH7A1,HDC,ALDH9A1B,ABP1,AOC1,CNDP1 |
| Chemical carcinogenesis | MGST2,UGT1A4,GSTM4,AHA-1,UGT1A6,ADH7,UGT2A1,CCBL1,CYP3A41B,ADH4 |
| Metabolism of xenobiotics by cytochrome P | CBR2,MGST1,UGT1A9,UGT1A2,GSTA5,UGT2B15,UGT1A6A,UGT2A3,GSTO1,CYP1A |
| Metabolic pathways | DDOST,PTGS2A,PLCE1,CYP7A1A,ADH6,UGP2A,DOLK,PIK3C3,MAT1A,CYP2R1 |
| Tyrosine metabolism | PNMT,GSTZ1,IL4I1,MAOA,GOT1,AOX1,TYRP1,AOC2,HPDA,TYRP1B |
| beta-Alanine metabolism | CNDP2,AOC2,ALDH6A1,MLYCD,CNDP1,ALDH9A1B,HIBCH,UPB1,HADHAA,ALDH1B1 |
| Glycolysis / Gluconeogenesis | LDHAL6B,G6PC3,G6PCA.2,ADH4,PCK2,ALDH3A2,GPIA,PKM,ENO1A,MINPP1 |
Protein Function
ALDH3A1 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity,alcohol dehydrogenase (NADP+) activity,aldehyde dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH3A1 itself. We selected most functions ALDH3A1 had, and list some proteins which have the same functions with ALDH3A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde dehydrogenase [NAD(P)+] activity | ALDH3A2,ALDH3A2B,ALDH3A2A,ALDH3B1,ALDH3B2,ALDH1A3,ALDH2 |
| aldehyde dehydrogenase (NAD) activity | ALDH3A2B,ALDH16A1,ALDH2,ALDH1A3,ALDH7A1,ALDH3A2A,Aldh1a7,ALDH9A1B,ALDH1B1,ALDH9A1 |
| alcohol dehydrogenase (NADP+) activity | AKR1A1B,AKR1A1A,RDH14 |
| protein binding | CRYGC,PSPC1,TEN1,GPR125,SEPT3,BRD3,NME3,GFPT2,INTS9,PPP3CC |
| benzaldehyde dehydrogenase (NAD+) activity | Aldh1a7,ALDH1A1 |
| 3-chloroallyl aldehyde dehydrogenase activity | ALDH3B2,ALDH3A2A,ALDH1A1,ALDH9A1,ALDH2.1,Aldh1a7,ALDH3B1,ALDH3A2B,ALDH3A2 |
Interacting Protein
ALDH3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH3A1.
POT1;SRF;CYHR1
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References
- Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
- Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).
