ALDH1L1
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Official Full Name
aldehyde dehydrogenase 1 family, member L1 -
Overview
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning. -
Synonyms
ALDH1L1;aldehyde dehydrogenase 1 family, member L1;formyltetrahydrofolate dehydrogenase , FTHFD;cytosolic 10-formyltetrahydrofolate dehydrogenase;10 fTHF;cytosolic 10 formyltetrahydrofolate dehydrogenase;10-FTHFDH;formyltetrahydrofolate dehydrogena
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
ALDH1L1 involved in several pathways and played different roles in them. We selected most pathways ALDH1L1 participated on our site, such as Folate-Alcohol and Cancer Pathway,One Carbon Metabolism,One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| One carbon pool by folate | MTHFD1L,FTCD,SHMT1,SHMT2,MTHFD1,MTFMT,TYMS,AMT,MTHFD2L,MTHFR |
| Folate-Alcohol and Cancer Pathway | CYP2E1 |
| folate transformations I | MTHFSD,ALDH1L2,MTHFD2 |
| One Carbon Metabolism | MTFMT,MTHFS,MTHFD2,AHCY,FTCD,ST20-MTHFS |
Protein Function
ALDH1L1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity,catalytic activity,formyltetrahydrofolate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1L1 itself. We selected most functions ALDH1L1 had, and list some proteins which have the same functions with ALDH1L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde dehydrogenase (NAD) activity | ALDH16A1,ALDH8A1,ALDH1L2,ALDH7A1,ALDH9A1B,ALDH6A1,ALDH5A1,ALDH3B2,ALDH9A1A.1,ALDH4A1 |
| methyltransferase activity | PRMT8B,METTL8,NSUN5B,PRDM4,C2orf56,ALDH1L2,DIMT1,EHMT1,WBP7,METTL17 |
| hydroxymethyl-, formyl- and related transferase activity | ALDH1L2 |
| formyltetrahydrofolate dehydrogenase activity | ALDH1L2 |
| catalytic activity | PPM1H,FHIT,PARP3,HSD3B6,PCYT1BB,ACSL4B,GLULC,AZIN1A,GMPR2,ACSL1B |
Interacting Protein
ALDH1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1L1.
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References
- Dinh, ML; Koppel, SJ; et al. DISTRIBUTION OF GLIAL CELLS IN THE AUDITORY BRAINSTEM: NORMAL DEVELOPMENT AND EFFECTS OF UNILATERAL LESION. NEUROSCIENCE 278:237-252(2014).
- Huang, J; Zhang, L; et al. Global Transcriptome Analysis of Peripheral Blood Identifies the Most Significantly Down-regulated Genes Associated with Metabolism Regulation in Klinefelter Syndrome. MOLECULAR REPRODUCTION AND DEVELOPMENT 82:17-25(2015).
