AKT1S1
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Official Full Name
AKT1 substrate 1 (proline-rich) -
Overview
PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a prolin-rich domain and appears at about 40 kDa by SDS-PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of TOS-motif in its structure in the same way as p70 S6 kinase and 4E-P1 do as substrates of mTOR , then PRAS40 is phosphorylated by mTORC1 at Ser-183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal-transducing pathway through the mediation of not only PKB/Akt but also mTOR. -
Synonyms
AKT1S1;AKT1 substrate 1 (proline-rich);Lobe;PRAS40;proline-rich AKT1 substrate 1;40 kDa proline-rich AKT substrate;proline-rich Akt substrate, 40 kDa;OTTHUMP00000196757;PRAS40;OTTHUMP00000196758;Lobe;OTTHUMP00000196759;MGC2865;OTTHUMP00000196760;OTTHUMP00000196756;proline-rich Akt substrate of 40 kDa
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E. coli
- HEK293T
- Mamanlian cells
- His
- His&Myc
- GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
AKT1S1 involved in several pathways and played different roles in them. We selected most pathways AKT1S1 participated on our site, such as mTOR signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mTOR signaling pathway | INS2,TNF,PIK3R3A,PIK3R3B,RPS6KAL,RPTOR,EIF4BA,ULK3,PIK3CA,EIF4E2RS1 |
| AMPK signaling pathway | ELAVL1,TSC1,PPP2R5B,PRKAA1,CREB3L3,AKT1,CAB39L,INS,CREB3L4,FBP2 |
Protein Function
AKT1S1 has several biochemical functions, for example, protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1S1 itself. We selected most functions AKT1S1 had, and list some proteins which have the same functions with AKT1S1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | PDLIM3A,TRIM35-35,LIMA1,RNF175,ADAM17A,RBM20,BRF2,CA9,EHMT1,ZNF146 |
| protein binding | TMEM119,HDAC9,GATA2,CDC34,PI4KB,SRPK3,STUB1,KIRREL2,CTSG,EIF1AY |
Interacting Protein
AKT1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1S1.
MTOR;RPTOR;BMH1;YWHAB;YWHAH;YWHAZ;RPS6KA5;ITGB3BP;TCEA2;q81wa0_bacan;hisJ
AKT1S1 Related Signal Pathway
Resources
Research Area
Phospholipases, Small GTPases, and Other Molecules in the Akt PathwaymTOR Complexes
PI3K Pathway
Related Services
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References
