AKR1A1
-
Official Full Name
aldo-keto reductase family 1, member A1 (aldehyde reductase) -
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. -
Synonyms
AKR1A1;aldo-keto reductase family 1, member A1 (aldehyde reductase);alcohol dehydrogenase [NADP(+)];ALR;DD3;dihydrodiol dehydrogenase 3;aldehyde reductase;alcohol dehydrogenase;aldo-keto reductase family 1 member A1;ARM;ALDR1;MGC1380;MGC12529
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- E. coli
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
AKR1A1 involved in several pathways and played different roles in them. We selected most pathways AKR1A1 participated on our site, such as Benzo(a)pyrene metabolism,Biological oxidations,Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione conjugation | GSTO2,GGT6,GGTLC1,GSTK1 |
| Biological oxidations | AHCY,CYP2K22,GSTO2,CYP2A13,CYP2W1,CYP2J2,CYP2E1,CYP2R1,CYP21A2,ADH1B |
| Catabolism of glucuronate to xylulose-5-phosphate | OXSR1 |
| Biosynthesis of antibiotics | ANI_1_2390104,ADSL,SDS,SDSL,DAO,DLST,pykF,AK7,AK8,CS |
| Benzo(a)pyrene metabolism | AKR1C4,FAM84B,CYP3A4,AKR1C2,CYP1A1,CYP1B1 |
| Degradation of aromatic compounds | ADH5,AKR1A1B,AKR1A1A,RGN |
| Glycerolipid metabolism | MGLL,GLYCTK,PPAP2D,TAE1,AKR1B10,DGKG,AGPAT5,LPL,ALDH7A1,CEL.1 |
| Glycolysis / Gluconeogenesis | PKLR,ALDH9A1B,ADH7,GM5506,PFKMA,ADH1,ACSS2,LDHA,ALDH3B1,PGAM1 |
Protein Function
AKR1A1 has several biochemical functions, for example, L-glucuronate reductase activity,alditol:NADP+ 1-oxidoreductase activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1A1 itself. We selected most functions AKR1A1 had, and list some proteins which have the same functions with AKR1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | AIFM1,ACAD9,CIAPIN1,GLRX2,NDUFS2,NDUFV2,GCDHB,SH3BGRL3,COX7A3,HSD17B6 |
| protein binding | CIRBP,PELI3,TRAM1,ELMO1,RIC8,DNPEP,PIK3CA,OTX1,RPS27A,BNIP1 |
| alditol:NADP+ 1-oxidoreductase activity | Akr1b3,AKR1C21,AKR1B8,AKR1C2,AKR1C3,AKR1B7,AKR7A5,ADH4,AKR1B1,PRKRA |
Interacting Protein
AKR1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1A1.
TERF2IP;TERF1;q8czt6_yerpe;EXOSC4
Resources
Related Services
Related Products
References
