AJUBA
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Official Full Name
ajuba LIM protein -
Overview
Ajuba is a member of LIM domain containing proteins that contribute to cell fate determination and regulate cell proliferation and differentiation. Ajuba is also involved in the regulation of actin cytoskeleton dynamics and cell migration. Ajuba plays a important role in the regulation of the kinase activity of AURKA/Aurora A for mitotic commitment. Is also a component of the IL 1 signaling pathway modulating IL 1 induced NF kappa B activation by influencing the assembly and activity of the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Ajuba is also a negative regulator of the Wnt signaling pathway. -
Synonyms
AJUBA;ajuba LIM protein;JUB;LIM domain-containing protein ajuba;jub, ajuba homolog
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AJUBA-581R | Recombinant Rat AJUBA Protein | Mammalian Cell | Rat | His |
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| AJUBA-5096HCL | Recombinant Human JUB 293 Cell Lysate | HEK293 | Human | Non |
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| AJUBA-5097HCL | Recombinant Human JUB 293 Cell Lysate | HEK293 | Human | Non |
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| Ajuba-1252M | Recombinant Mouse Ajuba Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| AJUBA-237R | Recombinant Rat AJUBA Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| AJUBA-237R-B | Recombinant Rat AJUBA Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
AJUBA involved in several pathways and played different roles in them. We selected most pathways AJUBA participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AJUBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | ID2,FZD5,WNT3,BMPR1B,ACTB,WWC1,GDF5,PPP2R2A,SMAD2,WNT3A |
Protein Function
AJUBA has several biochemical functions, for example, actin filament binding,alpha-catenin binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AJUBA itself. We selected most functions AJUBA had, and list some proteins which have the same functions with AJUBA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GLYR1,THOC7,PRSS3,HIPK4,PKHD1L1,PPP1R16B,PLXNB2,PWWP2B,TMBIM6,TBK1 |
| zinc ion binding | CNOT4B,MARCH3,MMP2,MSL2A,TRIM71,TOP3A,PITRM1,KAT7B,DTX3L,ZNF259 |
| actin filament binding | SYNE1,MYH11,TTN,CAPZB,SCIN,MYH9A,CORO2A,CTNNA1,CORO1CA,ANTXR1 |
| alpha-catenin binding | CDH24,JUB,VCL,JUP,CTNNB1,CDH2,NUMB,JUPA,PKP3,PKP2 |
| chromatin binding | CDK9,MEIS1,NR5A5,OST4,WACA,ATOH1A,MCMBP,CBX1,CITED1,SMC1A |
| transcription corepressor activity | SP100,SKOR1A,IRF2BP2,WTIP,DNMT3B,E2F6,MSC,TFCP2L1,NFIL3,HIRA |
Interacting Protein
AJUBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AJUBA here. Most of them are supplied by our site. Hope this information will be useful for your research of AJUBA.
LATS2;SNAI1;SFN;GFI1B;cadh1_human_gene
AJUBA Related Signal Pathway
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