AIRE
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Official Full Name
autoimmune regulator -
Overview
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012] -
Synonyms
AIRE;autoimmune regulator;APS1;APSI;PGA1;AIRE1;APECED;autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.Coli/Yeast
- Mammalian Cells
- HEK293
- His
- Flag
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AIRE-3784H | Recombinant Human AIRE, His-tagged | E.Coli/Yeast | Human | His | 545 |
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| AIRE-6087Z | Recombinant Zebrafish AIRE | Mammalian Cells | Zebrafish | His |
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| AIRE-1123HFL | Recombinant Full Length Human AIRE Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| AIRE-1696H | Recombinant Human AIRE Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| AIRE-299H | Recombinant Human AIRE Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| AIRE-299H-B | Recombinant Human AIRE Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Aire-560M | Recombinant Mouse Aire Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
AIRE involved in several pathways and played different roles in them. We selected most pathways AIRE participated on our site, such as Ubiquitin mediated proteolysis,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2H,PIAS4,FLJ11011L,KEAP1,UBE2J1,RHOBTB2,FBXW7,UBE2N,FBXW11,UBA1 |
| Primary i | CD40LG,IGLL1,BLNK,TAP2,ORAI1, Cd79b,BTK,RFX5,AICDA,LCK |
| nodeficiency | CD79A,IKBKG,CD3E,RFXAP,ICOS,RFX5,UNG,ORAI1,RAG2,CD8B1 |
Protein Function
AIRE has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AIRE itself. We selected most functions AIRE had, and list some proteins which have the same functions with AIRE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| translation regulator activity | IGF2BP3,RPS9,IGF2BP1,RPS14,YBX2,IGF2BP2 |
| transcription regulatory region DNA binding | CBX4,SNCA,NR1D1,CEBPA,KLF2A,MTERFD3,MLL1,TCF7L1B,TA,SREBF1 |
| identical protein binding | YWHAZ,SID4,GNPNAT1,PTPRM,CCDC155,SHARPIN,LRRK2,CLDN11,AIM2,SRI |
| chromatin binding | PHF13,ZNF143,HMGB2B,FOXC1A,SIRT2,SOX15,HDAC7,GATA5,PAF1,PRKAA2 |
| histone binding | ANP32B,PRKCBB,SPTY2D1,HIST1H4H,USP3,ASF1A,TBL1XR1,RCC1,SART3,SMARCA4A |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | GABPA,PKNOX1,NKX2-5,FOXF2,HOXD8,NEUROD2,GATA2A,CEBPA,STAG2,PPARG |
| RNA polymerase II regulatory region sequence-specific DNA binding | CREB3L4,GATA2,AASS,MYOD1,MEF2D,CGGBP1,ARID3A,ZNF691,SP1,CUX2 |
| transcription cofactor activity | TADA2A,MED24,MED30,MAX,LDB1B,LDB2A,POU2AF1,KAT2B,ANKRA2,PIR |
| zinc ion binding | LIN28A,RNF20,KLF7,LMO1,TGFB1I1,MGRN1B,CAR13,BMI1,DNAJC21,DNMT5 |
Interacting Protein
AIRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIRE here. Most of them are supplied by our site. Hope this information will be useful for your research of AIRE.
HIST1H3D
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References
- Proust-Lemoine, E; et al. Addison's disease and auto-immunity. CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION 19:17-21(2015).
- Chida, N; Kobayashi, I; et al. Disease specificity of anti-tryptophan hydroxylase-1 and anti-AIE-75 autoantibodies in APECED and IPEX syndrome. CLINICAL IMMUNOLOGY 156:36-42(2015).
