AIPL1
-
Official Full Name
aryl hydrocarbon receptor interacting protein-like 1 -
Overview
Leber congenital amaurosis (LCA) accounts for at least 5% of all inherited retinal disease and is the most severe inherited retinopathy with the earliest age of onset. Individuals affected with LCA are diagnosed at birth or in the first few months of life with severely impaired vision or blindness, nystagmus and an abnormal or flat electroretinogram. The photoreceptor/pineal -expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, was mapped within the LCA4 candidate region. The protein contains three tetratricopeptide motifs, consistent with nuclear transport or chaperone activity. AIPL1 mutations may cause approximately 20% of recessive LCA. -
Synonyms
AIPL1;aryl hydrocarbon receptor interacting protein-like 1;aryl hydrocarbon receptor interacting protein like 1 , LCA4;aryl-hydrocarbon-interacting protein-like 1;LCA4;AIPL2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- N-GST
- N-His
- His&Fc&Avi
- Myc&DDK
Involved Pathway
AIPL1 involved in several pathways and played different roles in them. We selected most pathways AIPL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AIPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AIPL1 has several biochemical functions, for example, farnesylated protein binding,protein binding,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AIPL1 itself. We selected most functions AIPL1 had, and list some proteins which have the same functions with AIPL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | RUVBL2,SIL1,CANX,SRSF10,CALR3,PFDN6,SPG7,GRPEL1,TTC1,PTGES3 |
| protein binding | PLK4,SNRNP40,VPS29,HCFC1,C19orf46,INPP5A,TMSB4Y,NQO2,TAGLN2,PMF1 |
Interacting Protein
AIPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIPL1.
TINF2;NUB1;nub1_chlae_protein;ACD;POT1
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