AIM2
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Official Full Name
absent in melanoma 2 -
Overview
AIM2 (absent in melanoma 2) is an interferon-inducible protein containing an amino-terminal pyrin domain and carboxy-terminal HIN-200 domain that functions in innate immunity and tumor progression. Expression of AIM2 can inhibit cell growth and tumor form -
Synonyms
AIM2;absent in melanoma 2;interferon-inducible protein AIM2;PYHIN4
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
AIM2 involved in several pathways and played different roles in them. We selected most pathways AIM2 participated on our site, such as Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytosolic DNA-sensing pathway | RIPK1L,POLR3G,IFNA8,POLR3C,TREX1,LOC100033925,IKBKE,POLR3F,POLR2EB,ZBP1 |
Protein Function
AIM2 has several biochemical functions, for example, double-stranded DNA binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AIM2 itself. We selected most functions AIM2 had, and list some proteins which have the same functions with AIM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | PYDC3,XRCC5,MTERFD1,ERCC5,AKAP8,CGGBP1,TP73,ZNF638,DMC1,SAFB |
| protein binding | PDPK1,CELF1,FNIP1,LSM5,VMP1,WFIKKN1,RGS14,PSG5,LBX1,S100A8 |
| identical protein binding | AGXT2,PRNP,SNCAIP,HCN2,MCIN,ENTPD2,EIF2AK3,COMMD1,DES,NFKBIA |
Interacting Protein
AIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIM2.
PYCARD;CASP1;SQSTM1;dsdna_dcmdg:dcmdg
Resources
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References
- Suschak, JJ; Wang, SX; et al. Identification of Aim2 as a Sensor for DNA Vaccines. JOURNAL OF IMMUNOLOGY 194:630-636(2015).
- Kim, HY; Kim, SJ; et al. Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion. FEBS Journal 282:259-270(2015).
