AGTR1
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Official Full Name
angiotensin II receptor, type 1 -
Overview
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. -
Synonyms
AGTR1;angiotensin II receptor, type 1;AGTR1B, angiotensin receptor 1B;type-1 angiotensin II receptor;AG2S;AGTR1A;AT1;AT1B;AT2R1;AT2R1A;AT2R1B;HAT1R;Agtr 1;AGTR1_HUMAN;AGTR1B;Angiotensin II receptor type 1;Angiotensin II type 1 receptor;Angiotensin II type-1 receptor;AT 1B;AT 1r;At1a;AT1AR;AT1BR;Type 1 angiotensin II receptor;angiotensin receptor 1;angiotensin receptor 1B;type-1B angiotensin II receptor;AT1R
Recombinant Proteins
- Human
- Chicken
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Bovine
- Sus scrofa (Pig)
- Guinea pig
- Oryctolagus cuniculus (Rabbit)
- Dog
- Meleagris gallopavo (Wild turkey)
- Pan troglodytes
- Sheep
- HEK293
- Wheat Germ
- Mammalian Cell
- Yeast
- E.coli
- E.coli expression system
- Non
- GST
- His
- His&Flag
- His&Myc
- N-His-GST&C-Myc
Involved Pathway
AGTR1 involved in several pathways and played different roles in them. We selected most pathways AGTR1 participated on our site, such as ACE Inhibitor Pathway,Adrenergic signaling in cardiomyocytes,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (q) signalling events | RGS18,CHRM3,OPN4.1,EDNRA,PROKR2,CCK,PROKR1A,FPR-RS4,ARHGEF25,AGT |
| ACE Inhibitor Pathway | AGTR2,ATP6AP2,CYP11B2,CTSG,CMA1,ACE,AGT |
| Arf6 signaling events | GULP1,USP6,EGFR,ADRB2,ADAP1,KIF13B,ARAP2,EGF,EFNA1,FBXO8 |
| Adrenergic signaling in cardiomyocytes | Adcy4,TNNT2A,MAPK14A,CACNA1SA,ADCY7,AGTR1B,RAPGEF4,TNNI3,TNNC1,CAMK2G1 |
| Calcium signaling pathway | CYSLTR2,ADRB3,OXTR,CAMK4,GRIN1,ADORA2B,STIM1,CALM2B,ORAI3,CACNA1D |
| Aldosterone synthesis and secretion | PRKD2,ITPR3,PLCB4,CREB3L3,PRKCB,CALM1,LIPE,CYP11B2,PLCB3,Adcy4 |
| Class A/1 (Rhodopsin-like receptors) | PENKA,CCR5,GPR37L1,CYSLTR1,CXCL13,TRH,GPR55A,CCR1,RLN3,GPR31B |
| Angiopoietin receptor Tie2-mediated signaling | DOK2,GRB7,CDKN1A,BMX,CRK,ELF1,ELF2,GRB14 |
Protein Function
AGTR1 has several biochemical functions, for example, angiotensin type I receptor activity,angiotensin type II receptor activity,bradykinin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR1 itself. We selected most functions AGTR1 had, and list some proteins which have the same functions with AGTR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| angiotensin type I receptor activity | AGTR1B,AGTR1A |
| angiotensin type II receptor activity | AGTR1A,CXCR3.2,RXFP3.2B,AGTR1B,APLNRA,RXFP4,AGTR2,AGTRAP,APLNRB |
| protein heterodimerization activity | MPP7,ABCG8,BTBD11,HIST2H4A,LIFR,NFYBB,MAFGB,ANO2,PDSS2,PKNOX1 |
| protein binding | NOL6,PIKFYVE,KLK13,CTRC,PGM1,NUBP2,NPM1,RPAP1,ZMYND11,ADRB1 |
| bradykinin receptor binding | AGTR1A,ACE |
Interacting Protein
AGTR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR1.
AGT;AGT;ARRB1;GNAQ;PLCG1
AGTR1 Related Signal Pathway
Resources
Research Area
Peptide Receptors on Endothelial CellsNeurotransmitter G Protein-Coupled Receptors
Peptide Hormone G Protein-Coupled Receptors
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
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References