AGPAT5
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) -
Overview
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. -
Synonyms
AGPAT5;1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon);1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;FLJ11210;LPAAT e;LPAAT epsilon;1 acyl sn glycerol 3 phosphate acyltransferase epsilon;1 acylglycerol 3 phosphate O acyltransferase 5;1 AGP acyltransferase 5;1 AGPAT 5;1 AGPAT5;1-acylglycerol-3-phosphate O-acyltransferase 5;1-AGP acyltransferase 5;1-AGPAT 5;1AGPAT5;LPAAT-epsilon;Lysophosphatidic acid acyltransferase epsilon;PLCE_HUMAN;LPAATE
Recombinant Proteins
- Rhesus macaque
- Human
- Zebrafish
- Mouse
- Mus musculus
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Myc&DDK
- Non
- N-His
- His&Fc&Avi
Involved Pathway
AGPAT5 involved in several pathways and played different roles in them. We selected most pathways AGPAT5 participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CMAS,OXSM,NAPRT1,INPP1,MGAT4A,B3GNT1,MGAT1A,CEPT1,CYP2B19,NDUFB11 |
| Phospholipase D signaling pathway | LPAR6,PIK3R3,KRAS,PLCB1,Adcy4,RAF1,AVPR1B,DGKD,GRB2,PDGFRA |
| Glycerolipid metabolism | glpK,PNPLA3,PPAP2A,DGAT1A,AGK,STIL,LIPF,Akr1b3,DGKE,DGKQ |
| Glycerophospholipid metabolism | PLA2G4A,PLA2G12A,PLA2G2D,PMT,PTDSS1,DGKA,GPAM,DGKAA,PHYKPL,LPCAT3 |
Protein Function
AGPAT5 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT5 itself. We selected most functions AGPAT5 had, and list some proteins which have the same functions with AGPAT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SCFD1,NUP50,DTX2,CMTM5,TAS2R16,EMD,RAB3A,CSF2,TIMELESS,XRCC4 |
| 1-acylglycerol-3-phosphate O-acyltransferase activity | LCLAT1,AGPAT1,LPCAT2,AGPAT3,AGPAT2,AGPAT9,AGPAT9L,LYCAT,ABHD5,AGPAT4 |
Interacting Protein
AGPAT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT5.
UBQLN1;15-deoxy-delta(12,14;E2F3
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References
- Parks, BW; Sallam, T; et al. Genetic Architecture of Insulin Resistance in the Mouse. CELL METABOLISM 21:334-346(2015).
- Tan, S; Ding, KS; et al. Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2. BREAST CANCER RESEARCH 16:-(2014).
