AGPAT4
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) -
Overview
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. -
Synonyms
AGPAT4;1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta);1-acyl-sn-glycerol-3-phosphate acyltransferase delta;dJ473J16.2;LPAAT delta;1 acyl sn glycerol 3 phosphate acyltransferase delta;1 acylglycerol 3 phosphate O acyltransferase 4;1 AGP acyltransferase 4;Lysophosphatidic acid acyltransferase delta;1-AGPAT 4;1-AGP acyltransferase 4;lysophosphatidic acid acyltransferase-delta (LPAAT-delta);1-AGPAT4;LPAAT-delta;RP3-473J16.2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Cynomolgus
- Rat
- Bovine
- Mus musculus
- Macaca fascicularis
- Pongo Abelii
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In vitro E. coli expression system
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
AGPAT4 involved in several pathways and played different roles in them. We selected most pathways AGPAT4 participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerolipid metabolism | MOGAT3,PNLIP,Akr1b3,DGAT1,DGKQ,DGKAA,DGKE,GLA,DGAT1A,PNPLA3 |
| Glycerophospholipid metabolism | GPAT2,PGS1,DGKD,PLA2G10,PTDSS1A,LYPLA2,PNPLA6,AGPAT9L,PCYT1AB,CHATA |
| Metabolic pathways | NDUFA4L,PSPH,MCCC1,PRPS1B,OGDH,HEXB,QRSL1,NT5C3L,B3GNT3,MGAT5B |
| Phospholipase D signaling pathway | KRAS,GRM5,F2R,LPAR5,SOS1,PDGFD,PIK3CG,GRM2,GRM1,PPAP2C |
Protein Function
AGPAT4 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT4 itself. We selected most functions AGPAT4 had, and list some proteins which have the same functions with AGPAT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | AGPAT9L,LCLAT1,LYCAT,AGPAT1,AGPAT9,AGPAT3,AGPAT5,ABHD5,LPCAT2,AGPAT2 |
| protein binding | CCDC106,SH3GL3,CDC42EP1,CAV2,MAGI1,RPUSD3,IGFBP7,HLA-DRB3,BICC1,ERCC6 |
Interacting Protein
AGPAT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT4.
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References
- Sankella, S; Garg, A; et al. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2 Mice*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4762-4777(2014).
- Cortes, VA; Smalley, SV; et al. Divergent Metabolic Phenotype between Two Sisters with Congenital Generalized Lipodystrophy Due to Double AGPAT2 Homozygous Mutations. A Clinical, Genetic and In Silico Study. PLOS ONE 9:-(2014).
