AGPAT1
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) -
Overview
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. -
Synonyms
AGPAT1;1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha);1-acyl-sn-glycerol-3-phosphate acyltransferase alpha;1 AGPAT1;LPAAT alpha;LPAATA;MGC5423;1 acyl sn glycerol 3 phosphate acyltransferase alpha;1 acylglycerol 3 phosphate O acyltransferase 1 (acetoacetly Coenzyme A thiolase);1 acylglycerol 3 phosphate O acyltransferase 1 (lysophosphatidic acid acyltransferase alpha);1 acylglycerol 3 phosphate O acyltransferase 1;1 AGP acyltransferase 1;AGPAT 1;G15;Lysophosphatidic acid acyltransferase alpha;Lysophospholipid acyltransferase;MGC4007;OTTHUMP00000062693;Protein G15;1-AGPAT 1;1-AGP acyltransferase 1;1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase);1-AGPAT1;LPAAT-alpha
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Sheep
- Bovine
- Mus musculus
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
AGPAT1 involved in several pathways and played different roles in them. We selected most pathways AGPAT1 participated on our site, such as CDP-diacylglycerol biosynthesis,CDP-diacylglycerol biosynthesis I,ChREBP activates metabolic gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid biosynthesis | AWAT1,PLBD1,CPNE6,PLD4,AGPAT2,SLC44A5B,AGPAT6,CDIPT,CEPT1,CHKA |
| CDP-diacylglycerol biosynthesis I | AGPAT2 |
| Fat digestion and absorption | CLPS,GOT2,PLA2G5,MOGAT2,AGPAT2,FABP1,PLA2G2F,APOA4,MTTP,SCARB1 |
| Glycerophospholipid metabolism | DGKA,DGKE,LCAT,PTDSS1A,PLA2G12B,ETNPPL,CEPT1B,LPGAT1,PISD,DGKAA |
| CDP-diacylglycerol biosynthesis | GPAT2,CDS1,GK5,AGPAT6,AGPAT2 |
| Glycerolipid metabolism | ALDH7A1,ALDH2.2,LCLAT1,GPAT2,PNLIPRP1,AKR1B1L,LIPC,MBOAT1,DGKA,GLA |
| Fatty acid, triacylglycerol, and ketone body metabolism | SIN3B,AGPAT2,YAP1,MED9,TIAM2,MED8,ELOVL1A,ACOT13,DECR1,ANKRD1 |
Protein Function
AGPAT1 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT1 itself. We selected most functions AGPAT1 had, and list some proteins which have the same functions with AGPAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | ABHD5,AGPAT5,AGPAT9,LCLAT1,LPCAT2,LYCAT,AGPAT3,AGPAT4,AGPAT2,AGPAT9L |
| protein binding | AGTR2,NF1,PICK1,CKB,UBAC1,JAGN1,KARS,LSM2,CCNF,NACA |
Interacting Protein
AGPAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT1.
MEOX2;Hoxa1;MYC
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References
- Benatti, RO; Melo, AM; et al. Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring. BRITISH JOURNAL OF NUTRITION 111:2112-2122(2014).
- Guan, WH; Steffen, BT; et al. Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids Within the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. CIRCULATION-CARDIOVASCULAR GENETICS 7:321-331(2014).
