AFG3L2
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Official Full Name
AFG3 ATPase family gene 3-like 2 (S. cerevisiae) -
Overview
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. -
Synonyms
AFG3L2;AFG3 ATPase family gene 3-like 2 (S. cerevisiae);AFG3 (ATPase family gene 3, yeast) like 2 , AFG3 ATPase family gene 3 like 2 (yeast) , SCA28, spinocerebellar ataxia 28;AFG3-like protein 2;AFG3 (ATPase family gene 3, yeast) like 2;AFG3 ATPase family gene 3 like 2 (yeast);AFG3 ATPase family gene 3 like 2;AFG3 like protein 2;ATPase family gene 3 like 2;ATPase family gene 3 yeast;EC 3.4.24.-;FLJ25993;Paraplegin like protein;SCA28;Spinocerebellar ataxia 28;paraplegin-like protein;ATPase family gene 3, yeast
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AFG3L2-9459H | Recombinant Human AFG3L2, His-tagged | E.coli | Human | His | 449-797a.a. | |
| AFG3L2-1401M | Recombinant Mouse AFG3L2 Protein | Mammalian Cell | Mouse | His |
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| AFG3L2-26445TH | Recombinant Human AFG3L2, His-tagged | E.coli | Human | His | 5-169 a.a. |
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| AFG3L2-409H | Recombinant Human AFG3L2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AFG3L2-6249Z | Recombinant Zebrafish AFG3L2 | Mammalian Cell | Zebrafish | His |
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| AFG3L2-8987HCL | Recombinant Human AFG3L2 293 Cell Lysate | HEK293 | Human | Non |
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| AFG3L2-376M | Recombinant Mouse AFG3L2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| AFG3L2-376M-B | Recombinant Mouse AFG3L2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| AFG3L2-5205H | Recombinant Human AFG3L2 protein, GST-tagged | E.coli | Human | GST | 550-759aa |
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| AFG3L2-990HF | Recombinant Full Length Human AFG3L2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 797 amino acids |
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| RFL4960HF | Recombinant Full Length Human Afg3-Like Protein 2(Afg3L2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-797) |
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Involved Pathway
AFG3L2 involved in several pathways and played different roles in them. We selected most pathways AFG3L2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFG3L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AFG3L2 has several biochemical functions, for example, ATP binding,ATP-dependent peptidase activity,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AFG3L2 itself. We selected most functions AFG3L2 had, and list some proteins which have the same functions with AFG3L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | NAP1L4,HTRA2,CALRL2,DNAJB5,DNAJA3,PFDN1,HSP26,CDC37L1,TBCA,CANX |
| zinc ion binding | MTA2,LONRF2,LIMD1,TRIM5,LMO7,SF1,MICALL1,DEF8,CCS,MMP30 |
| ATP binding | DHX38,FGFR1,ABCC1,DHX35,VSIG8B,MB21D1,KIF19,PRKCD,ACTR3B,RAD17 |
| ATP-dependent peptidase activity | YME1L1,CRBN,LONRF2,LONRF3,SPG7,LONP1,LONRF1L |
| protein binding | RNF138,KIAA0247,IL32,GOLGA1,ZKSCAN5,GNG12,CCNB1,BAG2,KRTAP12-4,TMSB4Y |
| metallopeptidase activity | AMZ2,MMP14B,ADAM10,ERAP2,PAPPA2,BMP1B,ADAMTS13,MEP1A.1,STAMBPL1,LNPEP |
| metalloendopeptidase activity | MEP1B,HE2,MMP23BB,ADAM10,PAPPAA,MMP14,UQCRC2A,MMP19,NLN,C6AST4 |
Interacting Protein
AFG3L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFG3L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFG3L2.
BECN1;TNFRSF1A;CLN3;USP50;RAC2;MAPK8IP2;purL;PHC2;RNF167;15-deoxy-delta(12,14;Trip11;Cenpe;ELL2;E2F3;1C;Junb;Rc3h2;USF1;Bmpr1a
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