ADRB3
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Official Full Name
adrenergic receptor, beta 3 -
Overview
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate;catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located;mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. -
Synonyms
ADRB3;adrenergic receptor, beta 3;beta-3 adrenergic receptor;ADR B3;ADRB 3;ADRB3_HUMAN;ADRB3R;Adrenergic beta 3 receptor;B3AR;Beta 3 adrenoceptor;Beta 3 adrenoreceptor;Beta 3AR;Beta-3 adrenoceptor;Beta-3 adrenoreceptor;Beta3AR;FLJ99960;Beta-3 AR;beta 3-AR;OTTMUSP00000036279;beta3-adrenergic receptor;Adrb-3
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Cynomolgus
- Rat
- Bovine
- Mus musculus
- Sus scrofa (Pig)
- Dog
- Macaca mulatta
- Goat
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Guinea pig
- Sheep
- Felis catus
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
ADRB3 involved in several pathways and played different roles in them. We selected most pathways ADRB3 participated on our site, such as Adrenoceptors,Amine ligand-binding receptors,Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (s) signalling events | VIP2,RXFP2B,RAMP2,PTHRP2,PTH2,PTHLH,PTHLHA,ADCYAP1,CRHR2,CRHB |
| Endocytosis | VTA1,GIT1,CLINT1A,DNM3,RAB35B,STAM,SNX3,FAM125A,CHMP4B,HLA-C |
| GPCR downstream signaling | RHOC,PYY,DCLRE1B,APPB,OR2AP1,TRH,CCR6,GPBAR1,NTS,FGD2 |
| Class A/1 (Rhodopsin-like receptors) | CCR1,LPAR1,DRD5,GPR4,RGS1,ADRB2,CCBP2,PRLH,MLN,CCL35.1 |
| Adrenoceptors | ADRB1,ADRA1D,ADRA1B,ADRB2,ADRa1A,ADRA2A,ADRA2C,ADRA2B |
| Amine ligand-binding receptors | CHRM2,ADRB2,ADRA2C,CHRM5,ADRA1B,CHRM1,DRD3,ADRa1A,DRD1,DRD5 |
| Calcium signaling pathway | TMEM8C,CYSLTR2,PPIFB,SLC8A1B,DRD1A,PTGER1A,CHRNA7,PTGER1,PLCD1,CACNA1DA |
| Calcium Regulation in the Cardiac Cell | GJB1,GJA4,CX55.5,CHRM5,PKIB,GJC1,CX27.5,RGS11,RGS10,YWHAQ |
Protein Function
ADRB3 has several biochemical functions, for example, beta-3 adrenergic receptor binding,beta-adrenergic receptor activity,beta3-adrenergic receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB3 itself. We selected most functions ADRB3 had, and list some proteins which have the same functions with ADRB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | SPATA24,AIMP1,TCF3A,PEX11A,SNX6,E2F8,ZNF174,LRP6,GDNFA,SNX2 |
| epinephrine binding | ADRA2B,ADRB2,ADRA2A,ADRA2C,ADRB3A,ADRB3B,ADRB2A,ADRB1,ADRB2B |
| beta-adrenergic receptor activity | ADRB1 |
| protein binding | PMM1,Casp3,CRB1,ANK1,PRPF8,PIPOX,PPARG,CAV2,GATA1A,GRK5 |
| beta-3 adrenergic receptor binding | ARRDC3 |
| beta3-adrenergic receptor activity | ADRB3A,ADRB3B |
Interacting Protein
ADRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB3.
Cav3;Nos3;Nos1
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