ADRA2A
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Official Full Name
Adrenergic, Alpha-2A-, Receptor -
Overview
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. -
Synonyms
Adra2a;adrenergic, alpha-2A-, receptor;RG20;CA2-47;RATRG20;adrenergic receptor, alpha 2a;Adrenergic alpha 2A receptor;Adrenergic, alpha 2A, receptor;alpha-2AAR;alpha-2A adrenoceptor;alpha-2A adrenoreceptor;alpha-2A adrenergic receptor;alpha-2D adrenergic receptor
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Pig
- zebrafish
- Sus scrofa (Pig)
- Guinea pig
- Bovine
- Mus musculus
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
ADRA2A involved in several pathways and played different roles in them. We selected most pathways ADRA2A participated on our site, such as Adrenaline signalling through Alpha-2 adrenergic receptor,Adrenaline,noradrenaline inhibits insulin secretion,Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amine ligand-binding receptors | CHRM1,ADRA1B,ADRA2B,ADRA1D,TAAR1,HRH3,ADRB2,DRD5,DRD3,CHRM4 |
| Adrenoceptors | ADRB1,ADRA1B,ADRA2C,ADRB2,ADRA2B,ADRA1D,ADRB3,ADRa1A |
| Class A/1 (Rhodopsin-like receptors) | CHRM2,PENK,CCL27,CXCR6,CCK,NPB,SSTR4,ADRA2C,TAC1,ADORA2B |
| G alpha (z) signalling events | RGS19,RGS17,RGS20,ADRA2B,ADRA2C,RGS4 |
| Adrenaline,noradrenaline inhibits insulin secretion | GNB3A,GNB5B,GNB5A,GNB3B,ADCY6,ADRA2C,GNB5 |
| Adrenaline signalling through Alpha-2 adrenergic receptor | ADRA2B,ADRA2C |
| GPCR downstream signaling | GCGA,RGS18,HEBP1,ANXA1B,ADM2,SCT,PYY,PENKA,RGS17,ADCYAP1 |
| G alpha (i) signalling events | OXGR1A.3,S1PR1,NPB,OPN1SW,AMCF-II,RLN3,TAS2R16,ADRA2C,NMUR1,GPR18 |
Protein Function
ADRA2A has several biochemical functions, for example, alpha-1B adrenergic receptor binding,alpha-2C adrenergic receptor binding,alpha2-adrenergic receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA2A itself. We selected most functions ADRA2A had, and list some proteins which have the same functions with ADRA2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | RHEB,TRAF4,RPS19,CRY1,AXIN2,TRPV4,AGTR1A,PIFO,NPR1,TTN |
| norepinephrine binding | ADRB3B,ADRB1,ADRB2,ADRB3A |
| protein homodimerization activity | IL12B,SMAD1,CBS,RAB11FIP3,MGST1,IL17F,DMRT1,CSF1,BIRC5,SH3GLB1 |
| alpha-1B adrenergic receptor binding | ARRB2,ARRB1 |
| protein heterodimerization activity | SCGB2A1,BRAF,SDCBP,EFHA1,BARD1,HIST1H2BF,STX1A,PRMT5,JAM2A,UGT1A6A |
| alpha-2C adrenergic receptor binding | APLP1 |
| epinephrine binding | ADRB2A,ADRB3B,ADRA2B,ADRB2,ADRB3,ADRA2C,ADRB2B,ADRB3A,ADRB1 |
| protein binding | GNA14,AIMP2,CAPNS1,RAB11FIP5,PTMA,RPL7,CLN6,HHLA3,USH1G,HMGB4 |
| thioesterase binding | TRAF4,RAC1,TRAF3,CDC42,TRAF6,TRAF5,TRAF1,HAUS7,CALM3,TRAF2 |
Interacting Protein
ADRA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA2A.
yohimbine;rx-821002;PSMD2;Usp19;Hacd3
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References
- Degos, V; Le Charpentier, T; et al. Neuroprotective Effects of Dexmedetomidine against Glutamate Agonist-induced Neuronal Cell Death Are Related to Increased Astrocyte Brain-derived Neurotrophic Factor Expression. ANESTHESIOLOGY 118:1123-1132(2013).
- Hua, XY; Chason, KD; et al. G(s)-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 344:426-435(2013).
