ADORA1
-
Official Full Name
adenosine A1 receptor -
Overview
inhibits adenylyl cyclase activity; plays a role in regulation of arterial pressure, heart rate, and sodium excretion [RGD, Feb 2006] -
Synonyms
ADORA1;adenosine A1 receptor;adenosine receptor A1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Guinea pig
- Chicken
- Rat
- Zebrafish
- Oryctolagus cuniculus (Rabbit)
- Bovine
- Mus musculus
- Pongo Abelii
- Dog
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- In vitro E. coli expression system
- E.coli expression system
- GST
- His
- Non
- His&Flag
- His&Fc&Avi
Involved Pathway
ADORA1 involved in several pathways and played different roles in them. We selected most pathways ADORA1 participated on our site, such as Adenosine P1 receptors,Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADORA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | INSL3,PROKR2,ADRA2B,CASR,RLN3A,LPAR2B,S1PR3,RHOAE,RHOB,ANXA1 |
| G alpha (i) signalling events | OXGR1A.1,DRD3,ANXA1A,TAS2R16,PENKA,AMCF-II,ANXA1B,OPN1LW1,CCR1,SSTR5 |
| Adenosine P1 receptors | ADORA3,ADORA2B,ADORA2A |
| GPCRs, Class A Rhodopsin-like | CCR1,GPR65,GPR171,GPR63,GPR4,OPN1LW,CX3CR1,SSTR2,OR10A5,CCR9 |
| GPCR ligand binding | EMR2,PTGDR2,CCL35.1,NMBB,AMCF-II,ADM2,OPN1SW1,EDN2,ADCYAP1B,RLN3A |
| Neuroactive ligand-receptor interaction | PTAFR,GRIA2A,MTNR1BB,NPFFR1L2,C3AR1,P2RY14,TAAR10D,GRM5,GRM2A,SSTR1 |
| Class A/1 (Rhodopsin-like receptors) | CCR5,UTS2D,TRH,MLN,CCK,ADRA1B,CCR6,ACKR4,ADRB1,OPN4A |
Protein Function
ADORA1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,G-protein coupled adenosine receptor activity,G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADORA1 itself. We selected most functions ADORA1 had, and list some proteins which have the same functions with ADORA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | GNAL,DNAJA1,UCN3L,ITGB4,GNAI2,NPFF,GHRL,GNAI2B,GNA11A,GNA11B |
| protein binding | CDK15,APOA2,ADAMTS10,CCNY,CACNA1SB,UBASH3B,UPF1,KRTAP10-4,BFSP2,AGPAT1 |
| G-protein coupled adenosine receptor activity | ADORA2AB,ADORA2B,ADORA3,ADORA2A,ADORA2AA,P2RY12 |
| purine nucleoside binding | ADA,C6orf130 |
| protein heterodimerization activity | ZFP423,GCA,RXRA,UGT1A2,CREB3L3,GRIN1,HIST1H4K,PDSS1,FZD1,SYT16 |
| heterotrimeric G-protein binding | CETN2,CETN4,ADRA2A,CETN1 |
| G-protein beta/gamma-subunit complex binding | CETN1,GNAS,GNA15,GNA13B,GNAI2B,GNA11,GNAL,GNAIA,GNA12A,GNAI2 |
| phospholipase C activity | PLCB4,PLCH2,PLCB2,PLCG1,PLCL1,PLCB3,PLCE1,PDIA3,PLCG2 |
Interacting Protein
ADORA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADORA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADORA1.
ADORA2A;dpcpx;SNF8
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