ADHFE1
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Official Full Name
alcohol dehydrogenase, iron containing, 1 -
Overview
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of;4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 (PubMed 16616524)). -
Synonyms
ADHFE1;alcohol dehydrogenase, iron containing, 1;hydroxyacid-oxoacid transhydrogenase, mitochondrial;FLJ32430;Fe containing alcohol dehydrogenase;ADH8;ADHFE 1;HOT;Hydroxyacid oxoacid transhydrogenase, mitochondrial;alcohol dehydrogenase 8;Fe-containing alcohol dehydrogenase 1;alcohol dehydrogenase iron-containing protein 1;HMFT2263
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rat
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADHFE1-11815Z | Recombinant Zebrafish ADHFE1 | Mammalian Cells | Zebrafish | His |
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| ADHFE1-1358M | Recombinant Mouse ADHFE1 Protein | Mammalian Cells | Mouse | His |
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| ADHFE1-355H | Recombinant Human ADHFE1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ADHFE1-527R | Recombinant Rat ADHFE1 Protein | Mammalian Cells | Rat | His |
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| ADHFE1-32HCL | Recombinant Human ADHFE1 cell lysate | Human | Non |
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| ADHFE1-183R | Recombinant Rat ADHFE1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| ADHFE1-183R-B | Recombinant Rat ADHFE1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ADHFE1-346M | Recombinant Mouse ADHFE1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ADHFE1-346M-B | Recombinant Mouse ADHFE1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ADHFE1-944HF | Recombinant Full Length Human ADHFE1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 419 amino acids |
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Involved Pathway
ADHFE1 involved in several pathways and played different roles in them. We selected most pathways ADHFE1 participated on our site, such as Interconversion of 2-oxoglutarate and 2-hydroxyglutarate,Metabolism,Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADHFE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyruvate metabolism and Citric Acid (TCA) cycle | PDK3B,PDK4,PDK2B,D2HGDH,PDP1,SLC16A8,PDPR,PDK2,BRP44,SLC16A1 |
| Interconversion of 2-oxoglutarate and 2-hydroxyglutarate | D2HGDH |
| The citric acid (TCA) cycle and respiratory electron transport | TIMMDC1,NDUFAF6,UCP2,C2orf56,TACO1,NDUFAF7,BRP44,LRPPRC,NDUFAF4,COX16 |
| Metabolism | SLC26A2,MED26,ETFB,BSG,LBR,ACOT11A,ALOX5AP,UGT1B7,GLB1L,UGT1B3 |
Protein Function
ADHFE1 has several biochemical functions, for example, hydroxyacid-oxoacid transhydrogenase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADHFE1 itself. We selected most functions ADHFE1 had, and list some proteins which have the same functions with ADHFE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | BAK1,E4F1,ALKBH5,GNAT2,ZNF311,RFK,MT1X,TIMP3,ZNF705A,GTPBP8 |
Interacting Protein
ADHFE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADHFE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADHFE1.
LIPC;GNAQ
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References
- Moon, JW; Lee, SK; et al. Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells. BMC CANCER 14:-(2014).
- Otte, J; Mall, A; et al. Malonic Semialdehyde Reductase from the Archaeon Nitrosopumilus maritimus Is Involved in the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 81:1700-1707(2015).
