ADH7
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Official Full Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -
Overview
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. -
Synonyms
ADH7;alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide;alcohol dehydrogenase class 4 mu/sigma chain;ADH 4;ADH 7;ADH4;Alcohol dehydrogenase class IV mu/sigma chain;Gastric alcohol dehydrogenase;Retinol dehydrogenase;alcohol dehydrogenase-7;alcohol dehydrogenase VII;class IV sigma-1 alcohol dehydrogenase;class IV sigmasigma alcohol dehydrogenase
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- HEK293
- E.Coli/Yeast
- Wheat Germ
- E.coli
- Yeast
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- SUMO
- DDK
- Myc
Involved Pathway
ADH7 involved in several pathways and played different roles in them. We selected most pathways ADH7 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | GSTM1,SULT1A2,ADH2-2,UGT1A7,CCBL2,SULT1A1,GSTT2,ADH2-1,FAM84B,UGT1A6B |
| Glycolysis / Gluconeogenesis | PGAM1B,PDHA2,PFKL,PKM,PGM2,TPI1B,PKLR,AKR1A1,PFKM,PFKMB |
| Ethanol oxidation | ADH1B,ADH1A,ADH8B,ADH1C,ADH8A,ADH4,ADH5,ADH6 |
| Fatty Acid Omega Oxidation | CYP2E1,CYP4A11,ADH4,CYP2A6,ADH1A,ADH1B,CYP2D6,ADH6,CYP1A1,ADH1C |
| Biological oxidations | CYP2C8,COMT,FDXR,GSTO2,CYP2E1,CYP3C4,CYP51A1,CYP11B1,TPMT.2,PRKRA |
| Metabolic pathways | MTMR1,ITGB1BP3,PLA2G4F,NT5E,GPAT2,HSD17B10,LPCAT4,SGMS1,ACSM5,PIK3C2G |
| Fatty acid degradation | ACADSB,ACADM,CPT1A,ADH1B,ALDH3A2A,ACSL5,ADH4,ACSL1A,ALDH2.2,ACSBG1 |
| Drug metabolism - cytochrome P450 | CYP2B6,ADH2-1,GSTK1,CYP2D6,GSTO2,ADH6,CYP2C9,CYP2A6,ADH4,ADH2-2 |
Protein Function
ADH7 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity,alcohol dehydrogenase activity, zinc-dependent,aldehyde oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH7 itself. We selected most functions ADH7 had, and list some proteins which have the same functions with ADH7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde oxidase activity | AOX3L1,AOX3,AOX4,AOX1 |
| retinol dehydrogenase activity | RDH12,SDR9C7,AKR1C3,RDH11,DHRS7C,SDR16C5,ADH4,RDH10,RDH5,RDH8 |
| retinol binding | RBP7,CRABP1,RBP5,RBP3,RLBP1,LRAT,ADH4,RBP2,CRABP2,C8G |
| alcohol dehydrogenase (NAD) activity | ADH1,ADH6,ADH8B,DHRS9,ADH1A,ADH1C,ADH5,ADH4,ADH8A |
| receptor antagonist activity | IL18BP,LRPAP1,AGTR2,ESR2,DKK1 |
| alcohol dehydrogenase activity, zinc-dependent | ADH1A,ADH4,ADH1B |
| zinc ion binding | CA5,TRIM35-31,LIMS3,ZZEF1,PRDM4,MMP24,ZNF276,NR2F2,FBLIM1,RNF144B |
| ethanol binding | ADH4,ADH1,PRKCE |
Interacting Protein
ADH7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH7.
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