ADH6

  • Official Full Name

    alcohol dehydrogenase 6 (class V)

  • Overview

    This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5 UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    ADH6;alcohol dehydrogenase 6 (class V);alcohol dehydrogenase 6;ADH 5;ADH 6;Aldehyde reductase;Class V alcohol dehydrogenase 6;UDP GLUCURONOSYLTRANSFERASE 2B10 PRECURSOR, MICROSOMAL;OTTHUMP00000161647;OTTHUMP00000161648;OTTHUMP00000161649;OTTHUMP00000220107;ADH-5

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    ADH6 involved in several pathways and played different roles in them. We selected most pathways ADH6 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty Acid Omega Oxidation ADH1B,CYP2A6,ADH4,CYP2D6,ADH1C,CYP1A1,ADH1A,CYP4A11,CYP2E1,ADH7
    Biological oxidations SLC26A1,AADAC,ADH1A,SULT1ST5,CYP2D6,FDX1L,CYP17A1,CYP2N13,CYP2W1,CYP11B2
    Metabolic pathways ATP6V1D,QDPRB2,EBP,CYP2C54,FUT6,ACSL1B,OAT,DNMT3A,ALG12,AANAT1
    Glycolysis / Gluconeogenesis G6PC3,PFKM,ALDH2,ADH4,ALDOAB,BPGM,LDHA,ADH2-2,ENO1B,PDHA2
    Fatty acid degradation ADH5,GCDH,ALDH1B1,ALDH9A1,ALDH3A2,ACSL1B,ACSL4,ACAA1,ADH1,GCDHA
    Chemical carcinogenesis SULT1A2,UGT1A7C,NAT1,HSD11B1,UGT2B7,ADH4,CHRNA7,UGT1A6,GSTA4,MGST1
    Drug metabolism - cytochrome P450 GSTO2,CYP2C19,CYP2B6,ADH1A,ADH4,CYP2C8,CYP2D6,ADH7,CYP2A6,ADH1C
    Ethanol oxidation ADH1C,ADH8A,ADH4,ADH7,ADH5,ADH8B,ADH1A,ADH1B

    Protein Function

    ADH6 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH6 itself. We selected most functions ADH6 had, and list some proteins which have the same functions with ADH6. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding DNAJC21,ADAM33,RNF43,VPS8,PEX2,ABLIM1,TRIM62,BRD1,UQCRC1,BRPF1
    alcohol dehydrogenase (NAD) activity DHRS9,ADH5,ADH1C,ADH8B,ADH7,ADH4,ADH1,ADH8A,ADH1A

    Interacting Protein

    ADH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH6.

    TNIP1;ANKRD17;RSL1D1;KRAS;ARRB1;RPS29;RPAIN;RASSF5

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