ADH1C

  • Official Full Name

    alcohol dehydrogenase 1C (class I), gamma polypeptide

  • Overview

    This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.

  • Synonyms

    ADH1C;alcohol dehydrogenase 1C (class I), gamma polypeptide;ADH3;alcohol dehydrogenase 1C;Alcohol dehydrogenase 3;Class I alcohol dehydrogenase;ADH gamma subunit;ADH1G_HUMAN;Alcohol dehydrogenase 1C (class I) gamma polypeptide;Alcohol dehydrogenase 1C gamma polypeptide;Alcohol dehydrogenase 3 (class I) gamma polypeptide;Alcohol dehydrogenase subunit gamma;Aldehyde reductase;OTTHUMP00000220209;ADH, gamma subunit;alcohol dehydrogenase 3 (class I), gamma polypeptide

Recombinant Proteins

  • Human
  • Rat
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADH1C-9418H Recombinant Human ADH1C, His-tagged E.coli Human His 1-374a.a.
ADH1C-2480H Recombinant Human Alcohol Dehydrogenase 1C (class I), Gamma Polypeptide, His-tagged E.coli Human His 1-375aa
ADH1C-346H Recombinant Human ADH1C Protein, GST-tagged Wheat Germ Human GST
ADH1C-523R Recombinant Rat ADH1C Protein Mammalian Cell Rat His
ADH1C-9013HCL Recombinant Human ADH1C 293 Cell Lysate HEK293 Human Non
ADH1C-0055H Recombinant Human ADH1C Protein (S2-F375), Tag Free E.coli Human Non S2-F375
ADH1C-0056H Recombinant Human ADH1C Protein (S2-F375), His tagged E.coli Human His S2-F375
ADH1C-09HF Recombinant Full Length Human ADH1C Protein In Vitro Cell Free System Human Full L. 375 amino acids
ADH1C-100H Recombinant Human ADH1C Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
ADH1C-179R Recombinant Rat ADH1C Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ADH1C-179R-B Recombinant Rat ADH1C Protein Pre-coupled Magnetic Beads HEK293 Rat
ADH1C-2487H Recombinant Human ADH1C protein, GST-tagged E.coli Human GST 1-375aa
ADH1C-27094TH Recombinant Human ADH1C Wheat Germ Human Non 375 amino acids
ADH1C-77H Recombinant Human ADH1C Protein, His&GST-tagged E.coli Human His&GST Ser2-Phe375
ADH1C-925HF Recombinant Full Length Human ADH1C Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 375 amino acids

    Involved Pathway

    ADH1C involved in several pathways and played different roles in them. We selected most pathways ADH1C participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Drug metabolism - cytochrome P450 GSTK1,CYP3A5,CYP2C9,CYP2E1,ADH4,CYP2B6,GSTO2,ADH5,ADH1B,CYP2C8
    Fatty Acid Omega Oxidation CYP1A1,CYP2E1,CYP2A6,ADH6,ADH7,ADH1A,CYP4A11,ADH4,ADH1B,CYP2D6
    Chemical carcinogenesis CYP2B19,ADH2-1,GSTP1,ADH1,CYP2E1,CYP2C50,CYP3A7-CYP3AP1,GSTT2,GSTK1,ADH4
    Fatty acid degradation ALDH1B1,HADHAA,ECI2,ADH4,HADHB,ACSL1,ECI1,ALDH3A2,ACAT1,ACSL4
    Biological oxidations GLYAT,SLC26A2,ACY3,CYP11B1,CYP2D6,ADH1A,ABHD10,CYP3A4,SLC35B2,CYP2K17
    Glycolysis / Gluconeogenesis PCK2,ADH6,GPIA,FBP1A,ALDH2.1,GPIB,GPI,ALDOAA,GM5506,ALDH2.2
    Metabolic pathways RRM1,ATP6V1F,GUSB,BCO1L,DPYS,PPAP2D,PGM2,MT-ND4,Amy1,SI
    Ethanol oxidation ADH7,ADH8A,ADH1A,ADH5,ADH4,ADH8B,ADH6,ADH1B

    Protein Function

    ADH1C has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1C itself. We selected most functions ADH1C had, and list some proteins which have the same functions with ADH1C. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding ADAMTS8,ADAMTS20,LMO2,TNP2,ZDHHC3A,CA9,PRICKLE2A,FNTB,ZFAND4,SETDB1A
    alcohol dehydrogenase (NAD) activity ADH1,ADH8A,DHRS9,ADH7,ADH4,ADH5,ADH8B,ADH6,ADH1A

    Interacting Protein

    ADH1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1C here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1C.

    Resources

    References

    • Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).
    • Chiang, CP; Jao, SW; et al. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. ALCOHOL 46:37-49(2012).

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