ADD2
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Official Full Name
adducin 2 (beta) -
Overview
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. -
Synonyms
ADD2;adducin 2 (beta);beta-adducin;ADDB;ADD 2;ADDB_HUMAN;Adducin2;Beta adducin;Erythrocyte adducin subunit beta;OTTHUMP00000203378;OTTHUMP00000203908
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- E.coli
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ADD2 involved in several pathways and played different roles in them. We selected most pathways ADD2 participated on our site, such as Miscellaneous transport and binding events,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | ABCE1,SLC26A3.2,ABCA7,ABCA4A,SLC10A6,CLCN1A,SLC30A2,AQP10B,SLC22A15,RHCGA |
| Miscellaneous transport and binding events | NIPA1,MRS2,AZGP1,ANKHA,MAGT1,NIPAL3,ADD1,ANKHB,ADD3,ANKH |
Protein Function
ADD2 has several biochemical functions, for example, actin binding,actin filament binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD2 itself. We selected most functions ADD2 had, and list some proteins which have the same functions with ADD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | BMP7A,RELA,PAFAH1B2,SNX5,POLA1,ADRB1,POLA2,H2-AA,ADRa1A,HIST1H2AG |
| actin binding | KLHL3,HPCA,MYHC4,INO80,PFN3,DNASE1,MYH7B,DST,MYO6,TNNT2A |
| actin filament binding | PLDN,SHROOM2,FSCN2,WIPF1,CTNNA1,SYNE2,NEXN,CORO1A,CORO2B,LCP1 |
| spectrin binding | PTPRN,USH1C,DYNC1I1,SPTAN1,STX4A,GNB1,UNC13A,EPB49,KIF3A,PDE6G |
| calmodulin binding | PDE1A,TRPM4,CAMK2B1,CAMK1GB,SLC8A1,PPP3CC,STRN,DAPK1,CNN3A,GAP43 |
| protein homodimerization activity | ATPIF1A,GDNFA,QDPR,ACOT7,PDCD6IP,DMRT3,TSG101,LRRFIP1,UXS1,SUMF1 |
Interacting Protein
ADD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD2.
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References
- Farghaian, H; Turnley, AM; et al. Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3. JOURNAL OF BIOLOGICAL CHEMISTRY 286:25274-25283(2011).
- Ogawa, Y; Rasband, MN; et al. Proteomic Analysis of Optic Nerve Lipid Rafts Reveals New Paranodal Proteins. JOURNAL OF NEUROSCIENCE RESEARCH 87:3502-3510(2009).
