ADCY6

  • Official Full Name

    adenylate cyclase 6
  • Overview

    This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.
  • Synonyms

    ADCY6;adenylate cyclase 6;adenylate cyclase type 6;AC6;ACVI;ADCY 6;ADCYB;Adenylate cyclase type VI;ATP pyrophosphate lyase 6;Ca(2+) inhibitable adenylyl cyclase;DKFZp779F075;EC 4.6.1.1;KIAA0422;adenylyl cyclase 6;ATP pyrophosphate-lyase 6;ca(2+)-inhibitable adenylyl cyclase
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADCY6-9409H Recombinant Human ADCY6 protein, GST-tagged E.coli Human GST 310-655 a.a.
ADCY6-3178H Recombinant Human ADCY6, GST-tagged E.Coli/Yeast Human GST 1168
ADCY6-330H Recombinant Human ADCY6 Protein, GST-tagged Wheat Germ Human GST
Adcy6-6931M Recombinant Mouse Adcy6 protein, His & T7-tagged E.coli Mouse His&T7 Gln314~Asn501
ADCY6-9410H Recombinant Human ADCY6 protein, His-tagged E.coli Human His Val246-Gly435

    Involved Pathway

    ADCY6 involved in several pathways and played different roles in them. We selected most pathways ADCY6 participated on our site, such as Activation of GABAB receptors,Adenylate cyclase activating pathway,Adenylate cyclase inhibitory pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of GABAB receptors GNGT2A,ADCY1,KCNJ12,ADCY3,ADCY7,KCNJ6,KCNJ5,KCNJ2,ADCY9,KCNJ10
    Aldosterone synthesis and secretion PRKD3,LIPE,STAR,PRKCE,CREB3L2,CAMK2B,Adcy4,DAGLB,NR4A1,SCARB1
    Adrenaline,noradrenaline inhibits insulin secretion ADRA2A,GNB3B,GNB5B,GNB5,ADRA2C,GNB3A,GNB5A
    Adenylate cyclase inhibitory pathway ADCY1,ADCY9,ADCY7,ADCY3,ADCY8
    Bile secretion SLCO1B1,NR0B2,HMGCR,SLC4A4,ATP1B3,OSTA,SCARB1,FXYD2,ATP1B4,SLCO1A5
    Adenylate cyclase activating pathway ADCY7,ADCY8,ADCY1,ADCY9,ADCY3
    Aquaporin-mediated transport MYO5B,AQP3A,GNB5B,PRKAR1AA,MIPB,AQP6,AQP10,ADCY8,GNB5,ADCY7
    Adrenergic signaling in cardiomyocytes CAMK2G1,ADCY3,CAMK2B,AGTR1,ADCY9,ADCY8,PLCB3,PIK3R1,PIK3R3,AGTR2

    Protein Function

    ADCY6 has several biochemical functions, for example, ATP binding,adenylate cyclase activity,calcium- and calmodulin-responsive adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY6 itself. We selected most functions ADCY6 had, and list some proteins which have the same functions with ADCY6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding VCP,UCK2,PL10,TRIT1,HELZ2,HSP90B1,NLK2,CAMK2G,MYO15,MYO3A
    scaffold protein binding CACNA1G,SRC,GRIN2A,HOMER1,TREM1,KRT15,GRID2,KCNH2,KRT5,CHRNA7
    metal ion binding GFI1B,PICK1,STK25,GUCY1B3,ZNF543,ARSB,ZFP326,NME6,RNASEL,HMGCL
    calcium- and calmodulin-responsive adenylate cyclase activity ADCY3,ADCY8,ADCY1
    protein binding PRKAB2,IGFBP2,PI4KB,CUL2,GEMIN7,C5orf30,Tnfrsf23,NDRG1,MICAL1,EFCAB11
    protein kinase binding RFFL,MAP2K6,MAP2K3,FGR,TRIM6,GSK3B,PPP1R15A,CCNE1,RACGAP1,GRB7
    adenylate cyclase activity ADCY7,ADCY8,ADCY3,ADCY1B,ADCY1,ADCY1A,ADCY2B,Adcy4,GNAS,ADCY9

    Interacting Protein

    ADCY6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY6.

    ATXN1

    ADCY6 Related Signal Pathway

    Resources

    References

    • Cunha-Reis, D; Aidil-Carvalho, MD; et al. Endogenous Inhibition of Hippocampal LTD and Depotentiation by Vasoactive Intestinal Peptide VPAC(1) Receptors. HIPPOCAMPUS 24:1353-1363(2014).
    • Dirix, V; Mielcarek, N; et al. Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin. MICROBES AND INFECTION 16:562-570(2014).

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