ACTB
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Official Full Name
actin, beta -
Overview
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008] -
Synonyms
ACTB;actin, beta;BRWS1;PS1TP5BP1;actin, cytoplasmic 1;beta cytoskeletal actin;PS1TP5-binding protein 1
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- Mouse
- Rat
- Chicken
- Cricetulus Griseus
- Porcine
- Human Platelet
- Mammalian Cell
- Wheat Germ
- E.coli
- E.Coli or Yeast
- HEK293
- Yeast
- Mammalian cells
- HEK293T
- Porcine brain
- Insect Cells
- Non
- His
- GST
- Myc&DDK
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
ACTB involved in several pathways and played different roles in them. We selected most pathways ACTB participated on our site, such as Rap signaling pathway,Phagosome,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | CAMK2B,PIK3R2,PRKACB,WNT11,RHOA,ROCK2,PXN,FGFR1,MAP2K1,TP53 |
| Phagosome | FCAR,C1R,RAC1,HLA-DRB3,VAMP3,ATP6V1C1B,ATP6V1G1,HLA-DMB,MRC1,NOS1 |
| Leukocyte transendothelial migration | ROCK2,MYL7,CLDN4,RAP1A,RAP1B,PTK2,ACTN3,CLDN18,CLDN15,NCF1 |
| Pathogenic Escherichia coli infection | YWHAZ,EZR,HCLS1,ROCK1,CLDN1,TUBB2B,TLR4,CDC42,PRKCA,TUBA1B |
| Shigellosis | RAC1,ROCK2,MAPK9,MAPK3,NFKBIA,IKBKB,U2AF1L4,WAS,CTTN,CDC42 |
| Rap signaling pathway | VAV2,GNAI3,SIPA1L1,FYB,MAP2K1,FGFR2,INS,GNAI1,RHOA,GRIN1 |
| Dilated cardiomyopathy | RYR2,ADRB1,SGCD,LAMA2,CACNG2,ITGA1,TPM1,ITGA8,Itga10&Itgb1,LMNA |
| Regulation of Actin Cytoskeleton | ARPC5LA,FN1,WASB,FGF7,FGF11A,PDGFRA,GNA12A,EGFRA,EZRB,ITGB1A |
| Hippo signaling pathway | BMP8B,PRKCZ,WNT10B,SMAD7,WNT16,FZD9,CDH1,TEAD1,GDF6,ID1 |
Protein Function
ACTB has several biochemical functions, for example, ATP binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTB itself. We selected most functions ACTB had, and list some proteins which have the same functions with ACTB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to nucleosomal DNA binding | SMARCC2,MBD3,HDAC1,SMARCB1,GATAD2B,CHD4,RBBP4,MTA2,ACTL6A,SMARCC1 |
| ATP binding | HSP90B1,RAD51B,STK38L,P2RY4,CKM,BMX,TTLL6,SIK2,PIK3C3,IFIH1 |
| identical protein binding | PIP4K2C,E2F7,C1QL4,STK10,CLDN6,GOT2B,TP53,BAK1,CALHM1,TPRGL |
| kinesin binding | KLC3,MAPK8IP3,SERPINB1A,IFT88,CLSTN1,KIFAP3,AP1AR,AP1G1,NEFH,ATCAY |
| protein binding | LAMA4,SCFD1,SAP30L,FABP5,MITF,POLR3F,HNF4A,TCEA1,USP18,TSN |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | HDAC2,SMARCE1,SMARCA4,SMARCC1,SMARCC2,MBD3,ACTL6A,SMARCB1,GATAD2B,MTA2 |
| structural constituent of cytoskeleton | TUBB,CYLC1,TUBA8L,TUBA1B,SORBS3,BKJ,TUBA1A,TLN2A,TUBA1L,TUBA3C |
| nitric-oxide synthase binding | ATP2B4,CD74,CALM3,DMD,SLC6A4,CALM2,SCN5A,DNM3,SLC14A2,CDH2 |
| Tat protein binding | TRIM32,NPM1,GABARAPL1,SMARCB1,MDFIC,SMARCA4,DLL1 |
Interacting Protein
ACTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTB here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTB.
ACTG1;CFL1;DSTN;ESR1
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References
- Bonnans, C; Lohela, M; et al. Real-time Imaging of Myeloid Cells Dynamics in Apc(Min/+) Intestinal Tumors by Spinning Disk Confocal Microscopy. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).
- Matsumoto, C; Ito, M; et al. Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 73:245-252(2013).
