ACTA1

  • Official Full Name

    actin, alpha 1, skeletal muscle

  • Overview

    The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.

  • Synonyms

    ACTA1;actin, alpha 1, skeletal muscle;ACTA;actin, alpha skeletal muscle;alpha-actin-1;alpha skeletal muscle actin;ASMA;CFTD;MPFD;NEM1;NEM2;NEM3;CFTD1;CFTDM

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Bovine
  • Rat
  • Rabbit
  • Porcine
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • E.Coli or Yeast
  • HEK293
  • Rat Serum
  • Pigeon Serum
  • Insect cells
  • Rabbit skeletal muscle
  • Porcine skeletal muscle
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACTA1-305H Recombinant Human ACTA1 protein, His-tagged E.coli Human His 1-377 aa
ACTA1-306H Recombinant Human ACTA1 protein, GST-tagged E.coli Human GST 1-377 aa
ACTA1-1238M Recombinant Mouse ACTA1 Protein Mammalian Cell Mouse His
ACTA1-125H Recombinant Human ACTA1 protein, GST-tagged Wheat Germ Human GST 1-377 a.a.
ACTA1-2743C Recombinant Chicken ACTA1 Mammalian Cell Chicken His
ACTA1-3090B Recombinant Bovine ACTA1, His-tagged E.Coli or Yeast Bovine His 377
Acta1-3091R Recombinant Rat Acta1, His-tagged E.Coli or Yeast Rat His 377
ACTA1-477R Recombinant Rat ACTA1 Protein Mammalian Cell Rat His
ACTA1-7HCL Recombinant Human ACTA1 lysate HEK293 Human Non
ACTA1-133R Recombinant Rat ACTA1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ACTA1-133R-B Recombinant Rat ACTA1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ACTA1-157R Native Rabbit skeletal muscle alpha Actin Rat Serum Rabbit Non Full length native Rabbit skeletal muscle alpha Actin
Acta1-158M Native Mouse skeletal muscle alpha Actin Pigeon Serum Mouse Non Full length native mouse skeletal muscle alpha Actin
ACTA1-281M Recombinant Mouse ACTA1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ACTA1-281M-B Recombinant Mouse ACTA1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ACTA1-304H Recombinant Human ACTA1 Protein (3-377 aa), His-tagged E.coli Human His 3-377 aa
ACTA1-564H Recombinant Human ACTA1 protein, His-tagged Insect cells Human His 3-377aa
ACTA1-853R Native Rabbit ACTA1 Protein Rabbit skeletal muscle Rabbit Non 375 amino acids
ACTA1-854P Native Porcine ACTA1 Protein Porcine skeletal muscle Porcine Non 375 amino acids

    Involved Pathway

    ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis,Hypothetical Network for Drug Addiction,Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by focal adhesion kinase ARHGAP26,KLF8,ARHGEF28,BMX
    RhoA signaling pathway CYR61,MKL1,DIAPH1
    Caspase cascade in apoptosis CRADD,LMNB1,DIABLO,CASP4,CASP2,CFL2,TFAP2A,PARP1,TOP1,SATB1
    Hypothetical Network for Drug Addiction GJB7,CX28.8,ACTA1B,NISCH,TERF2IP,ZHX2
    Striated Muscle Contraction TMEM8C,TNNT3B,TNNT3,VIML,TNNI2B.1,ACTA1B,DESMB,TNNI2B.2,TNNI2A.3,TNNI1
    Myometrial Relaxation and Contraction Pathways IGFBP4,IGFBP6,RGS6,RAMP1,PKIG,CRCP,RXFP2,RGS4,MYLK2,ATF5

    Protein Function

    ACTA1 has several biochemical functions, for example, ADP binding,ATP binding,myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FGFBP1,KLF11,NUDCD3,GLS2,DERL2,NF1,COX5B,PAM16,PTPRC,MMS19
    myosin binding VAMP2,ACTC1,SLC6A4,DMD,MYBPC3,CALD1B,CALD1,GIPC1,USH2A,SMYD1B
    ATP binding KDRL,NME2B.2,FLT4,EPHB4,CHORDC1,FLT1,BMP2K,CDK7,SMARCA5,UBE2J2
    structural constituent of cytoskeleton F-KER,BFSP2,TUBA1A,TUBB2A,TLN2A,PLS1,CTNNA2,MSN,ARPC4,NEFL
    ADP binding PRPS2,VCP,LONP1,MYH10,PRPS1,ERN1,HSP104,PRKAG2,MYO6,MYO7A

    Interacting Protein

    ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.

    HTRA2;DNASE1;GC;GSN;ssh-2;Kcnma1;SSH3;SSH1;ZNF16;TNNI3K;TRIM63;RNF167;SMURF2;CD247;ARRB1;BTK;LRRK2;TRAF3IP1;LRCH3

    Resources

    References

    • Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
    • Nakagawa, Y; Inoue, H; et al. Molecular biological analysis of cardiac effect of high temperature in rats. LEGAL MEDICINE 14:63-68(2012).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All ACTA1 Products

    Required fields are marked with *

    My Review for All ACTA1 Products

    Required fields are marked with *