ACSL4

  • Official Full Name

    acyl-CoA synthetase long-chain family member 4
  • Overview

    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
  • Synonyms

    ACSL4;acyl-CoA synthetase long-chain family member 4;FACL4, fatty acid Coenzyme A ligase, long chain 4 , mental retardation, X linked 63 , mental retardation, X linked 68 , MRX63, MRX68;long-chain-fatty-acid--CoA ligase 4;long chain fatty acid Coen

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • DDK
  • Myc
  • Non
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACSL4-0414H Recombinant Human ACSL4 protein, His-tagged E.coli Human His 143-236 aa
ACSL4-198H Recombinant Human ACSL4 Protein, GST-tagged Wheat Germ Human GST
ACSL4-199H Recombinant Human ACSL4 Protein, GST-tagged Wheat Germ Human GST
ACSL4-218R Recombinant Rhesus monkey ACSL4 Protein, His-tagged Mammalian Cells Rhesus macaque His
ACSL4-471R Recombinant Rat ACSL4 Protein Mammalian Cells Rat His
ACSL4-9074H Recombinant Human ACSL4 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
ACSL4-9074HCL Recombinant Human ACSL4 293 Cell Lysate HEK293 Human Non
ACSL4-9075HCL Recombinant Human ACSL4 293 Cell Lysate HEK293 Human Non
ACSL4-127R Recombinant Rat ACSL4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ACSL4-127R-B Recombinant Rat ACSL4 Protein Pre-coupled Magnetic Beads HEK293 Rat
Acsl4-1507M Recombinant Mouse Acsl4 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
ACSL4-3160HFL Recombinant Full Length Human ACSL4 protein, Flag-tagged Mammalian Cells Human Flag Full L.
ACSL4-46R Recombinant Rhesus Macaque ACSL4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
ACSL4-46R-B Recombinant Rhesus Macaque ACSL4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ACSL4-55H Recombinant Human ACSL4 Protein, His-tagged E.coli Human His Lys500-Lys711
Acsl4-56R Recombinant Rat Acsl4 Protein, His-tagged E.coli Rat His Lys459-Lys670
Acsl4-5993M Recombinant Mouse Acsl4 protein, His-tagged E.coli Mouse His 100-581aa
ACSL4-5997H Recombinant Human ACSL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
ACSL4-796HF Recombinant Full Length Human ACSL4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 670 amino acids
ADAMTS5-3533H Recombinant Human ADAMTS5 protein, His-tagged E.coli Human His 417-558 aa
RFL-6383HF Recombinant Full Length Human Long-Chain-Fatty-Acid--Coa Ligase 4(Acsl4) Protein, His-Tagged E.coli Human His Full L. Full Length (1-711)

    Involved Pathway

    ACSL4 involved in several pathways and played different roles in them. We selected most pathways ACSL4 participated on our site, such as Fatty acid biosynthesis,Fatty acid degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adipocytokine signaling pathway NFKBIAA,PPARAB,ADIPOQB,RXRGB,RXRAA,TRADD,JAK2B,CPT1A,CHUK,RELA
    Fatty Acid Biosynthesis OXSM,ECHDC3,ACACB,ACSL4B,ACSL3,ACSL3A,FASN,ACSL5,ACSL1A,ECHDC2
    Metabolic pathways CYP4A14,B3GNT5,NDUFB2,HSD17B6,MVD,GALM,PTGES3A,NDUFA8,MGAT5,UQCRC2
    Fatty acid metabolism HSD17B12B,MECR,FADS2,ELOVL5,TECRB,PTPLA,ACADVL,ACAT1,ACSL1,SCDB
    Peroxisome ACSL4A,CRATA,SLC25A17,PHYH,PIPOX,SOD2,MVK,CAT,DAO.1,PEX11B
    PPAR signaling pathway FABP6,FABP7,PLTP,APOA1A,SCDB,Scd1,ACOX3,ACAA1,FABP7B,ACSL5
    Fatty acid degradation ACSL1,ACOX1,ADH2-1,ADH2-2,ECI1,GCDHB,ADH7,ALDH9A1,HADHAB,CPT1B

    Protein Function

    ACSL4 has several biochemical functions, for example, ATP binding,arachidonate-CoA ligase activity,long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL4 itself. We selected most functions ACSL4 had, and list some proteins which have the same functions with ACSL4. You can find most of the proteins on our site.

    Function Related Protein
    very long-chain fatty acid-CoA ligase activity SLC27A4,SLC27A2,SLC27A1B,SLC27A1A,SLC27A3,SLC27A5,ACSBG1
    ATP binding CSNK2A1,AAK1,ACSM1,EPHB2,EPHA2A,CDK16,RPS6KAL,DCLK3,ACVR1C,ACTB1
    long-chain fatty acid-CoA ligase activity SLC27A2,ACSBG1,ACSL5,ACSL3,SLC27A4,SLC27A1A,SLC27A5,SLC27A1B,SLC27A3,ACSBG2

    Interacting Protein

    ACSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL4.

    YWHAZ;DSE;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;ACSL3;1C;ABCG1;MRPS15;SLC1A5;TJAP1;SPG20;EDEM1;BRF1;UVRAG;p27958-pro_0000037575;TMEM173

    Resources

    References

    • Tuohetahuntila, M; Spee, B; et al. Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1851:220-230(2015).
    • Xu, WD; Yang, XY; et al. Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study. JOURNAL OF PROTEOMICS 113:57-72(2015).

    Ask a Question for All ACSL4 Products

    Required fields are marked with *

    My Review for All ACSL4 Products

    Required fields are marked with *