ACR

  • Official Full Name

    acrosin

  • Overview

    Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.

  • Synonyms

    ACR;acrosin;preproacrosin;Acrosin precursor;ACRS;Proacrosin

Recombinant Proteins

  • Rat
  • Mouse
  • Goat
  • Human
  • Rabbit
  • Turkey
  • E.coli
  • E.Coli/Yeast
  • Mammalian Cells
  • HEK293
  • Yeast
  • Insect Cells
  • His
  • GST
  • Avi
  • Fc
  • MBP
  • Myc
  • Non

    Involved Pathway

    ACR involved in several pathways and played different roles in them. We selected most pathways ACR participated on our site, such as Acrosome Reaction,Fertilization,Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fertilization OVGP1,ZP3,IZUMO1,ZP2,ADAM20,HVCN1,CATSPER1,CATSPERB,CATSPERG2,ADAM2
    Reproduction TMEM146,CATSPERG1,CATSPERB,CATSPER1,CATSPERG2,IZUMO1,CATSPER2,ZP3,CATSPER3,ADAM20

    Protein Function

    ACR has several biochemical functions, for example, hydrolase activity,mannose binding,peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACR itself. We selected most functions ACR had, and list some proteins which have the same functions with ACR. You can find most of the proteins on our site.

    Function Related Protein
    hydrolase activity PGAM1,GLS,CNOT6,HDHD1,DUSP22B,NOTUM1B,STAMBPA,KLK1B24,ELA2,C9orf156
    protein binding BFSP1,BEX1,LGR5,ZFAND2B,LRRIQ3,LDLR,WDR61,SEPT6,FTCD,PRADC1
    serine-type peptidase activity PRSS3,HTRA3,TMPRSS11E,HGFA,ENDOU,ELA2L,SEC11C,KLK10,OVCH2,TMPRSS11G
    mannose binding DPM1,CD209A,CD209,IGF2R,LMAN2L,MANBA,MAN2B1,M6PR,CD209C,CLEC4M
    serine-type endopeptidase activity CFI,TYSND1,PRTN3,MMP2,GZMA,PCSK7,HTRA2,PRSS38,CELA2A,LTF
    peptidase activity KEX2,NOTS,IWS1,KLK1B16,ELANE,ASTL,TMPRSS4A,USP9,USP43A,Casp3

    Interacting Protein

    ACR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACR here. Most of them are supplied by our site. Hope this information will be useful for your research of ACR.

    Resources

    References

    • Goncalves, MJ; Sousa, S; et al. Characterization of damage in Portuguese lupus patients: analysis of a national lupus registry. LUPUS 24:256-262(2015).
    • Amezcua-Guerra, LM; Higuera-Ortiz, V; et al. Performance of the 2012 Systemic Lupus International Collaborating Clinics and the 1997 American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in a Real-Life Scenario. ARTHRITIS CARE & RESEARCH 67:437-441(2015).

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