ACER2
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Official Full Name
alkaline ceramidase 2 -
Overview
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor,;sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate;sphingosine (Xu et al., 2006 (PubMed 16940153)). -
Synonyms
ACER2;alkaline ceramidase 2;ASAH3L, N acylsphingosine amidohydrolase 3 like;FLJ41587;haCER2;alkCDase 2;alkaline CDase 2;ceramide hydrolase;ASAH3L;ALKCDase2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALK-2573H | Recombinant Human ALK protein, His-tagged | E. coli | Human | N-His | 43-366 aa | |
| ASAH3L-879H | Recombinant Human ASAH3L protein, GST-tagged | Wheat Germ | Human | GST |
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| ACER2-1454HF | Recombinant Full Length Human ACER2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 226 amino acids |
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| RFL-14836HF | Recombinant Full Length Human Alkaline Ceramidase 2(Acer2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-275) |
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| RFL-19706MF | Recombinant Full Length Mouse Alkaline Ceramidase 2(Acer2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-275) |
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Involved Pathway
ACER2 involved in several pathways and played different roles in them. We selected most pathways ACER2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ACER2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ACER2 itself. We selected most functions ACER2 had, and list some proteins which have the same functions with ACER2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ACER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACER2.
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References
- Sasaki, H; Toyomura, K; et al. Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 550:12-19(2014).
- Snider, AJ; Wu, BX; et al. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. PROSTAGLANDINS & OTHER LIPID MEDIATORS 99:124-130(2012).
