ACCN2
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Official Full Name
amiloride-sensitive cation channel 2, neuronal -
Overview
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products. -
Synonyms
ACCN2;amiloride-sensitive cation channel 2, neuronal;ASIC1;BNaC2;hBNaC2;neuronal;ACCN2_HUMAN;Acid sensing ion channel 1;Acid sensing ion channel 1a protein;Acid sensing ion channel;Acid-sensing ion channel 1;AI843610;Amiloride sensitive cation channel 2 neuronal;Amiloride-sensitive cation channel 2;ASIC;ASIC1A;B530003N02Rik;Brain sodium channel 2;Cation channel amiloride sensitive neuronal 2;ACCN2 variant 3;acid-sensing ion channel 1a protein;Cation channel, amiloride-sensitive, neuronal, 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACCN2-204R | Recombinant Rhesus monkey ACCN2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ACCN2-3416C | Recombinant Chicken ACCN2 | Mammalian Cell | Chicken | His |
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| ACCN2-04HF | Recombinant Full Length Human ACCN2 Protein | In Vitro Cell Free System | Human | Full L. 528 amino acids |
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| ACCN2-26289TH | Recombinant Human ACCN2 | Wheat Germ | Human | Non | 528 amino acids |
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| ACCN2-33R | Recombinant Rhesus Macaque ACCN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ACCN2-33R-B | Recombinant Rhesus Macaque ACCN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ACCN2 involved in several pathways and played different roles in them. We selected most pathways ACCN2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ACCN2 has several biochemical functions, for example, acid-sensing ion channel activity,ion gated channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACCN2 itself. We selected most functions ACCN2 had, and list some proteins which have the same functions with ACCN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion gated channel activity | ASIC1 |
| acid-sensing ion channel activity | ASIC1B,ASIC1,ASIC1C,ASIC1A |
Interacting Protein
ACCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACCN2.
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References
- Sun, X; Zhao, D; et al. Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. ONCOLOGY REPORTS 30:2852-2858(2013).
- Mata, X; Ducasse, A; et al. Genomic structure, polymorphism and expression of ACCN1 and ACCN3 genes in the horse. ANIMAL GENETICS 41:138-144(2010).
